磁共振成像2025，Vol.16Issue(5)：44-48,5.DOI:10.12015/issn.1674-8034.2025.05.007
磁化传递成像评价胰腺导管腺癌纤维化的可行性研究
A feasibility study of magnetization transfer imaging on the evaluation of fibrosis in pancreatic duct adenocarcinoma
摘要
Abstract
Objective:To evaluate the ability of magnetization transfer imaging(MTI)in assessing the fibrosis of pancreatic ductal adenocarcinoma(PDAC).Materials and Methods:The clinical,imaging and pathological data of 53 patients with PDAC were analyzed retrospectively.All patients underwent MTI examination before surgery and the MTR values of the tumors were measured.Masson staining was used to evaluate tumor fibrosis.The percentage of tumor fibrous area were calculated by ImageJ software.Based on the degree of fibrosis,all patients were divided into two groups:high and low fibrosis.Independent sample t test and one-way ANOVA were used to compare the differences of the magnetic transfer rate(MTR)values and general characteristics between high-and low-grade fibrosis groups.Spearman correlation analysis was used to evaluate the correlation between MTR value and fibrosis degree of PDAC.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficiency of MTR value for PDAC fibrosis classification.Results:The MTR value of the low-grade fibrosis group was(0.158±0.053),and that of the high-grade fibrosis group was(0.230±0.063).There was a significant difference of MTR values between the two groups(t=-4.528,P＜0.001),while other general characteristics were not statistically significant(P＞0.05).ROC curve analysis showed that the AUC value of the MTR in evaluating the fibrosis of PDAC patients was 0.822.When a threshold was 0.496,the sensitivity and the specificity were 87.5％and 62.1％,respectively.Conclusions:As a non-invasive imaging index,MTR value has a potential application value in the evaluation of PDAC fibrosis.关键词
胰腺导管腺癌/磁化传递/磁共振成像/定量分析/纤维化Key words
pancreatic ductal adenocarcinoma/magnetization transfer/magnetic resonance imaging/quantitative analysis/fibrosis分类
医药卫生引用本文复制引用
沈志秋,杨明明,吕俊馨,张京刚,陈杰..磁化传递成像评价胰腺导管腺癌纤维化的可行性研究[J].磁共振成像,2025,16(5):44-48,5.基金项目
Research Project of Jiangsu Provincial Health Commission(No.ZD2022003) （No.ZD2022003）
Changzhou Applied Basic Research Program Project(No.CJ20244014). 江苏省卫生健康委科研项目(编号:ZD2022003) （No.CJ20244014）
常州市应用基础研究计划项目(编号:CJ20244014) （编号:CJ20244014）
