摘要
Abstract
Objective:To explore the brain regions and their neurobiomarkers that are vulnerable to brain activation and brain volume in patients with social isolation(SI).Materials and Methods:Chinese literature was searched using the Chinese search terms"social isolation""brain"and"magnetic resonance imaging"in Chinese databases including China National Knowledge Infrastructure,Wanfang,VIP,and the Chinese Biomedical Literature Database.English literature was searched using the English search terms"social isolation""brain,"and"magnetic resonance imaging"in English databases including PubMed,Web of Science,Cochrane Library,and Embase.Synonyms for both Chinese and English search terms were expanded,and the search period spanned from the establishment of the databases to September 2024.Literature was included according to strict inclusion and exclusion criteria.Activation likelihood estimation(ALE)was employed,and the single dataset module of Ginger ALE software was utilized to conduct an integrated analysis of the abnormal brain regions in SI patients compared to healthy controls(HCs)in previous studies.Results:A total of 10 studies from 10 articles were included(488 SI patients and 476 HCs),encompassing task-based functional magnetic resonance imaging(task-based fMRI)and structural magnetic resonance imaging(sMRI)studies.The meta-analysis results of task-based fMRI studies revealed that SI patients exhibited increased brain activation in the left parahippocampal gyrus and left amygdala compared to HCs(voxel volume 1640 mm3,P＜0.001),with no regions showing decreased brain activation.The meta-analysis results of sMRI studies indicated that SI patients had increased brain volume in the right lentiform nucleus,right lateral globus pallidus,and right fusiform gyrus compared to HCs(voxel volume 912,840 mm3,P＜0.001),and decreased brain volume in the left fusiform gyrus,right inferior frontal gyrus,and right middle occipital gyrus(voxel volume 480,448,448 mm3,P＜0.001).Conclusions:This study,through ALE Meta-analysis,identified that the brain regions susceptible to activation in SI patients are the left parahippocampal gyrus and the left amygdala.The brain regions susceptible to volume changes include the left fusiform gyrus,the right inferior frontal gyrus,the right middle occipital gyrus,the right lentiform nucleus,the right lateral globus pallidus,and the right fusiform gyrus.These findings contribute to a deeper understanding of the neural mechanisms underlying the impact of social isolation on the brain and provide a theoretical basis for preventing the negative effects of social isolation.关键词
脑/社交隔离/磁共振成像/激活似然估计法/Meta分析Key words
brain/social isolation/magnetic resonance imaging/activation likelihood estimation/Meta-analysis分类
医药卫生
