磁共振成像2025，Vol.16Issue(5)：223-228,6.DOI:10.12015/issn.1674-8034.2025.05.034
酰胺质子转移成像在子宫内膜癌中的研究进展
Progress of amide proton transfer imaging in endometrial cancer
摘要
Abstract
Amide proton transfer(APT)imaging is a novel chemical exchange saturation transfer technique that measures the exchange rate between amide protons of endogenous proteins or peptides and water protons in tissues,reflecting changes in protein concentration and the microenvironment.Endometrial carcinoma(EC)is a common malignant tumor of the female genital tract,with an incidence that is increasing year by year and becoming younger.Currently,APT imaging plays an important role in the differential diagnosis,pathological characteristics evaluation,immunohistochemical markers and molecular pathological expression prediction of endometrial cancer.However,most of the relevant studies have limited sample sizes,and the limitations of APT imaging technology and data processing affect the accuracy of the results.In the future,the implementation of multi-center large sample studies,combined with molecular subtypes,tumor genomics and multimodal imaging technology,and the improvement of image quality and standardization of data processing,will promote the development of precision diagnosis and treatment.This article reviews the technical principles of APT and its research in endometrial cancer.It is expected to help radiologists to have a more comprehensive understanding of the APT imaging manifestations and application prospects of endometrial cancer,and to provide objective information for clinical personalized diagnosis and treatment.关键词
子宫内膜癌/淋巴脉管间隙侵犯/磁共振成像/酰胺质子转移成像/组织学分级/免疫组化Key words
endometrial carcinoma/lymphovascular space invasion/magnetic resonance imaging/amide proton transfer imaging/histological grading/immunohistochemistry分类
医药卫生引用本文复制引用
曾莹婷,宁清灵,方斌,钟俭平,钟俊远..酰胺质子转移成像在子宫内膜癌中的研究进展[J].磁共振成像,2025,16(5):223-228,6.基金项目
Ganzhou Science and Technology Planning Project(No.GZ2024ZSF046). 赣州市科技计划项目(编号:GZ2024ZSF046) （No.GZ2024ZSF046）
