分子影像学杂志2025，Vol.48Issue(6)：661-667,7.DOI:10.12122/j.issn.1674-4500.2025.06.01
KARL 3D重建技术可降低胸部屏气PET/CT的辐射剂量
KARL 3D reconstruction technique can reduce radiation dose in breath-hold chest PET/CT
摘要
Abstract
Objective To investigate the application value of KARL 3D iterative reconstruction technology in chest breath-hold PET/CT scanning.Methods Ninety-three patients with suspected pulmonary nodules undergoing chest breath-hold PET/CT scans at the First Affiliated Hospital of Shandong First Medical University from March 2022 to March 2023 were prospectively enrolled.Participants were stratified into three groups(10,20,30 mAs)based on tube current settings for breath-hold attenuation correction CT(ACCT).ACCT images acquired under different low-dose protocols were reconstructed using both KARL 3D and conventional filtered back projection(FBP)algorithms.Quantitative comparisons of CTmean,noise(SD),and signal-to-noise ratio(SNR)were performed for the aorta,main pulmonary artery,and axillary adipose tissue between reconstruction methods.Comparative analysis was further conducted between KARL 3D-reconstructed images and FBP-reconstructed diagnostic-dose images(FBP-reconstructed 130-mAs images,FBP130)regarding SD,SNR,and effective dose(ED).Results At all dose levels,no statistically significant differences were observed in CT mean between KARL 3D and FBP reconstructions(P>0.05).After KARL 3D reconstruction,the standard deviation(SD)decreased and the SNR increased in the images,with statistically significant differences(P<0.001).For the 10 mAs and 20 mAs groups,KARL 3D-reconstructed images showed statistically significant differences in SD,SNR and ED compared with FBP130(P<0.001).The 30 mAs protocol combined with KARL 3D achieved comparable SD and SNR to FBP130(P>0.05),while reducing ED by 68%.Conclusion The 30 mAs protocol with KARL 3D(grade 5)reconstruction produces diagnostic-quality images equivalent to conventional high-resolution CT-FBP reconstructions,simultaneously achieving attenuation correction.This approach reduces radiation exposure by approximately 76%compared with conventional diagnostic CT plus low-dose ACCT protocols.关键词
正电子发射断层显像/KARL 3D迭代/滤波反投影/图像质量/低剂量Key words
positron-emission tomography/KARL 3D iterative/filter backup projection/image quality/low-dose引用本文复制引用
荆玉东,段艳华,柴雷英,高琳,崔晓,徐基伟,李慧,刘雯慧,李坤,程召平..KARL 3D重建技术可降低胸部屏气PET/CT的辐射剂量[J].分子影像学杂志,2025,48(6):661-667,7.基金项目
国家自然科学基金(82202235) （82202235）
山东省自然科学基金(ZR2022MH165) （ZR2022MH165）
山东省泰山学者项目(tsqn202312358) Supported by National Natural Science Foundation of China(82202235) （tsqn202312358）
