分子影像学杂志2025，Vol.48Issue(6)：678-683,6.DOI:10.12122/j.issn.1674-4500.2025.06.03
99mTc-EC肾动态显像联合Um-Alb、Uβ2-MG可有效诊断原发性干燥综合征肾损害
99m Tc-EC renal dynamic imaging combined with Um-Alb and Uβ2-MG can effectively diagnose renal involvement in primary Sjögren's syndrome
摘要
Abstract
Objective To explore the value of renal dynamic imaging combined with urinary microalbumin(Um-Alb)and urinary β2-microglobulin(Uβ2-MG)in the diagnosis of renal involvement in primary Sjögren's syndrome(pSS).Methods A retrospective analysis of 52 pSS patients attending our hospital from January 2019 to December 2023 included 33 patients in impaired renal function group and 19 in unimpaired renal function group.The renal function curve parameters,ERPF,Um-Alb,Uβ2-MG were collected and compared between the two groups,the diagnostic efficacy of ERPF,Um-Alb,Uβ2-MG and the three combination on pSS renal impairment was compared,and the combined model of the best diagnostic efficacy was constructed and visualized with the Nomogram.Results Between the two groups,time to peak wasn't prolonged,while pSS duration,half time of excretion and 20 min residual rate increased,ERPF was lower,Um-Alb and Uβ2-MG were higher than unimpaired renal function group,and the difference was statistically(P<0.05).ERPF,Um-Alb and Uβ2-MG had higher diagnostic efficacy of pSS renal damage,with AUC of 0.813,0.859 and 0.850 respectively and combined AUC of 0.992.Conclusion Renal dynamic imaging,ERPF combined with Um-Alb and Uβ2-MG can effectively diagnose pSS renal impairment,clinicians can predict the risk of pSS renal impairment and intervene early according to nomogram model.关键词
原发性干燥综合征/肾动态显像/尿微量白蛋白/尿β2-微球蛋白/诊断价值Key words
primary Sjögren's syndrome/renal dynamic imaging/Um-Alb/Uβ2-MG/diagnostic value引用本文复制引用
崔璨,温庆祥,孟元,田蕾,路素言,顾文,石瑾..99mTc-EC肾动态显像联合Um-Alb、Uβ2-MG可有效诊断原发性干燥综合征肾损害[J].分子影像学杂志,2025,48(6):678-683,6.基金项目
国家自然科学基金(82104847) （82104847）
北京市属医院科研培育计划项目(PZ2019013) Supported by National Natural Science Foundation of China(82104847) （PZ2019013）
