黑龙江科学2025，Vol.45Issue(5)：424-428,5.DOI:10.3969/j.issn.1001-5779.2025.05.002
抗氧化基因1与神经退行性疾病:从分子机制到靶向药物研究
Oxidation resistance gene 1 and neurodegenerative diseases:from molecular mechanisms to targeted drug research
摘要
Abstract
Oxidation resistance gene 1(OXR1),as an evolutionarily conserved endogenous antioxidant defense system core regulator,plays a key role in maintaining cellular redox homeostasis.Studies have shown that OXR1 can build a multi-level antioxidant defense network to protect cells from oxidative damage by regulating antioxidant pathways,maintain-ing mitochondrial function,and stabilizing the reverse transport complex.The abnormal expression of OXR1 is closely related to the occurrence and development of oxidative stress-related diseases(such as neurodegenerative diseases,cardio-vascular diseases and malignant tumors),but the mechanism of action is complex.This article reviews the structure,function,role,and pharmacological research of OXR1,providing a theoretical basis for understanding its involvement in neurodegenerative diseases and the development of OXR1-targeting drugs.关键词
抗氧化基因1/神经退行性疾病/氧化应激/活性氧Key words
Oxidation resistance gene 1/Neurodegenerative diseases/Oxidative stress/Reactive oxygen species分类
生物学引用本文复制引用
郑江,刘家豪,刘若萱,曾亮,钟毅,田原僮..抗氧化基因1与神经退行性疾病:从分子机制到靶向药物研究[J].黑龙江科学,2025,45(5):424-428,5.基金项目
国家自然科学基金项目(8236100501) （8236100501）
江西省教育厅科学技术研究项目(GJJ201503) （GJJ201503）
赣南医科大学研究生创新专项资金校级项目(YC2023-X008) （YC2023-X008）
