神经损伤与功能重建2025，Vol.20Issue(6)：后插1-后插1,1.DOI:10.16780/j.cnki.sjssgncj.202506015
CAR-T细胞疗法在中枢神经系统疾病中的现状与前景
Current State and Perspectives of CAR T Cell Therapy in Central Nervous System Diseases
Lena Kristina Pfeffer 1Felix Fischbach 1Christoph Heesen 1Manuel A Friese 1唐颖馨2
作者信息
- 1. Institute of Neuroimmunology and Multiple Sclerosis,University Medical Center Hamburg-Eppendorf,20251 Hamburg,Germany||Department of Neurology,University Medical Center Hamburg-Eppendorf,20246 Hamburg,Germany
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摘要
Abstract
B cell-directed CAR T cell therapy has fundamentally changed the treatment of haematological malignancies,and its scope of application is rapidly expanding to include other diseases such as solid tumours or autoimmune disorders.Therapy-refractoriness remains an important challenge in various inflammatory and non-inflammatory disorders of the CNS.The reasons for therapy failure are diverse and include the limited access current therapies have to the CNS,as well as enormous inter-and intra-individual disease heterogeneity.The tissue-penetrating properties of CAR T cells make them a promising option for overcoming this problem and tackling pathologies directly within the CNS.First application of B cell-directed CAR T cells in neuromyelitis optica spectrum disorder and multiple sclerosis patients has recently revealed promising outcomes,expanding the potential of CAR T cell therapy to encompass CNS diseases.Additionally,the optimization of CAR T cells for the therapy of gliomas is a growing field.As a further prospect,preclinical data reveal the potential benefits of CAR T cell therapy in the treatment of primary neurodegenerative diseases such as Alzheimer's disease.Considering the biotechnological optimizations in the field of T cell engineering,such as extension to target different antigens or variation of the modified T cell subtype,new and promising fields of CAR T cell application are rapidly opening up.These innovations offer the potential to address the complex pathophysiological properties of CNS diseases.To use CAR T cell therapy optimally to treat CNS diseases in the future while minimizing therapy risks,further mechanistic research and prospective controlled trials are needed to assess seriously the disease and patient-specific risk-benefit ratio.关键词
CAR-T细胞/胶质瘤/多发性硬化/神经退行性疾病/神经炎症Key words
CAR T cells/glioma/multiple sclerosis/neurodegeneration/neuroinflammation分类
临床医学引用本文复制引用
Lena Kristina Pfeffer,Felix Fischbach,Christoph Heesen,Manuel A Friese,唐颖馨..CAR-T细胞疗法在中枢神经系统疾病中的现状与前景[J].神经损伤与功能重建,2025,20(6):后插1-后插1,1.
