意大利肿瘤患者中心静脉导管相关血流感染的发生率及亚组分析的多中心横断面调查研究
Silvia Belloni Sergio Ferrante Daniela Strada Silvia Bonalumi Elena Pisano Paola Maisola Giulia Villa Arianna Magon Gianluca Conte Stefania Ducoli Marco Fadda Cristina Arrigoni Tedeschi Michele Rosario Caruso Marco Alfredo Arcidiacono Giovanni Boschi Alessandro Leonetti Maria Allevato Orejeta Diamanti Chiara Cardone Daniele Girardi
意大利肿瘤患者中心静脉导管相关血流感染的发生率及亚组分析的多中心横断面调查研究
Prevalence of central line-associated bloodstream infections in patients with cancer and subgroup analysis using propensity score matching:A nationwide multicenter study in Italy
摘要
Abstract
Objectives:This study aimed to analyze the prevalence of long-term central line-associated bloodstream infections(CLABSI)among hospitalized adults with cancer in Italy and compare the characteristics of patients who required long-term central venous access device(LCVAD)substitution due to prior CLABSI with those who had never experienced CLABSI. Methods:The study was conducted in hospitals across northern and central Italy using a multicenter,observational,cross-sectional design from March to September 2021.A total of 174 adults with cancer were included.Data were collected through electronic case report forms,including demographic,clinical,treatment-related,and catheter-related variables.Propensity score matching(PSM)was used to compare the characteristics of patients who underwent LCVAD substitution due to previous CLABSI with those who never experienced CLABSI.Multiple correspondence analysis(MCA)was conducted to explore the patterns within matched subgroups. Results:The prevalence of CLABSI was 3％,and 5.2％of patients required LCVAD substitution due to prior CLABSI.After applying PSM,the groups were successfully balanced for sex,age,presence of metastases,comorbidities,BMI,received treatments,corticosteroid therapy,ongoing antibiotics,hormone therapy,type of LCVAD,lumens,and utilization frequency.Hematologic cancer was more frequent in the CLABSI group(44.4％)compared to the non-infective group(0),with a statistically significant difference(P=0.045).MCA revealed potential patterns among matched subgroups but did not identify statistically significant associations:patients with previous LCVAD substitution were more frequently associated with a history of prior infections,ongoing antibiotic therapy,and unspecified primary lesion locations;conversely,patients who never experienced CLABSI tended to cluster around characteristics such as hormone therapy and corticosteroid therapy. Conclusions:These findings emphasize the importance of continuous monitoring,individualized infec-tion prevention strategies in oncology nursing practice.Future research with larger datasets is needed to validate these findings and develop tailored interventions to reduce CLABSI risks.关键词
肿瘤/中心静脉导管相关血流感染/多重对应分析/护理/倾向评分匹配Key words
Cancer/Central line-associated bloodstream infection/Multiple correspondence analysis/Nursing/Propensity score matching引用本文复制引用
Silvia Belloni,Sergio Ferrante,Daniela Strada,Silvia Bonalumi,Elena Pisano,Paola Maisola,Giulia Villa,Arianna Magon,Gianluca Conte,Stefania Ducoli,Marco Fadda,Cristina Arrigoni,Tedeschi Michele,Rosario Caruso,Marco Alfredo Arcidiacono,Giovanni Boschi,Alessandro Leonetti,Maria Allevato,Orejeta Diamanti,Chiara Cardone,Daniele Girardi..意大利肿瘤患者中心静脉导管相关血流感染的发生率及亚组分析的多中心横断面调查研究[J].国际护理科学（英文）,2025,12(3):276-284,9.基金项目
This study is part of a project that has received funding from the 5x1000 Humanitas funds.The Humanitas Research Foundation is a non-profit organization that operates at the University Research and Teaching Center of the Humanitas Clinical Institute in Rozzano.None of the researchers received income from the funding or had any role with the institution.The Foundation was not involved in the design nor the conduct of the study and will not benefit in any form from the investigation results.The publication fee for this work was covered by the Italian Ministry of Health's Ricerca'Cor-rente'funding to IRCCS Humanitas Research Hospital. （）
