康复学报2025，Vol.35Issue(3)：260-264,274,6.DOI:10.3724/SP.J.1329.2025.03005
靶向小脑-大脑神经环路的脑卒中康复:从神经调控到闭环式脑机接口技术的进展
Stroke Rehabilitation Targeting the Cerebello-Cerebral Neural Circuit:Advances from Neuromodulation to Closed-Loop Brain-Computer Interface Technology
摘要
Abstract
Stroke remains the leading cause of death and disability among adults in China.Approximately one-third of stroke survivors experience varying degrees of functional impairment,significantly diminishing their quality of life and necessitating fur-ther rehabilitation interventions.Traditional non-invasive neuromodulation techniques primarily target cortical regions,such as the dorsolateral prefrontal cortex and the primary motor cortex;however,their clinical efficacy varies considerably among individuals.Therefore,identifying additional rehabilitation targets is crucial for enhancing functional recovery in stroke patients.In recent years,the cerebello-cerebral neural circuit has garnered increasing attention due to its pivotal role in regulating both motor and cognitive functions.Stroke events profoundly impact this neural circuit,with the cerebellum serving as a key node and a promising target for post-stroke functional rehabilitation.This review aims to elucidate the effects of stroke on the cerebello-cerebral neural circuit,sum-marize recent advances in cerebellum-targeted neuromodulation techniques,and explore the potential of closed-loop brain-computer interface technology to modulate neural plasticity within this circuit to promote functional recovery in stroke patients.关键词
脑卒中/神经调控/脑机接口/小脑-大脑神经环路/康复Key words
stroke/neuromodulation/brain-computer interface/cerebello-cerebral neural circuit/rehabilitation引用本文复制引用
郭双辉,张玉梅..靶向小脑-大脑神经环路的脑卒中康复:从神经调控到闭环式脑机接口技术的进展[J].康复学报,2025,35(3):260-264,274,6.基金项目
国家自然科学基金面上项目(82372555) （82372555）
