广西医科大学学报2025，Vol.42Issue(3)：351-359,9.DOI:10.16190/j.cnki.45-1211/r.2025.03.004
SUMO特异性肽酶1在乳腺癌中的表达及其临床意义
Expression and clinical significance of SUMO-specific protease 1 in breast cancer
摘要
Abstract
Objective:To investigate the expression and its clinical significance of small ubiquitin-like modifier(SUMO/sentrin)-specific protease 1(SENP1)in breast cancer tissues.Methods:First,the UALCAN database was utilized to analyze the SENP1 expression levels in breast cancer patients.Subsequently,reverse transcription-quantitative polymerase chain reaction(RT-qPCR)was employed to examine the expression levels of SENP1 in different breast cell lines and 44 cases of breast cancer tissues,and explore its correlation with clinicopathological parameters.Meanwhile,immunohistochemical analysis was performed to assess protein expression levels of SENP1 in breast cancer tissues.Finally,immune infiltration analysis was conducted to analyze the relationship between SENP1 and immune cell infiltration.Results:UALCAN database analysis revealed significantly upregu-lated SENP1 expression in breast cancer tissues(P＜0.05).The expression of SENP1 was markedly elevated in MDA-MB-231,MCF7,and HCC1937 cell lines as well as breast cancer tissues(P＜0.05).The SENP1 levels in patients with high levels of Ki-67 was significantly higher than those in patients with lower levels of Ki-67(P＜0.05).SENP1 levels in patients with histological grade Ⅲ were significantly higher than those in patients with his-tological grade Ⅱ(P＜0.05);SENP1 levels were positively correlated with serum progesterone levels(P＜0.05).Bioinformatics analysis revealed that the infiltration of 10 types of immune cells,such as dendritic cells,was sig-nificantly decreased in patients with higher levels of SENP1(P＜0.05),while the infiltration of other 3 types of immune cells such as T helper cells,was significantly increased(P＜0.05).Conclusion:The expression of SENP1 is significantly upregulated in breast cancer tissues,which may promote the development of breast cancer by inhibiting immune cell infiltration.关键词
乳腺癌/SUMO特异性肽酶1/免疫细胞浸润Key words
breast cancer/SUMO-specific protease 1/immune cell infiltration分类
临床医学引用本文复制引用
冯小芳,王宇轩,徐慧洁,刘旗,刘务刚,朱懋媛,邓熙,覃凯,曾麒燕..SUMO特异性肽酶1在乳腺癌中的表达及其临床意义[J].广西医科大学学报,2025,42(3):351-359,9.基金项目
国家自然科学基金资助项目(No.82060387) （No.82060387）
国家级大学生创新创业训练计划资助项目(No.202210598009)[共同第一作者]冯小芳、王宇轩 （No.202210598009）
