广西医科大学学报2025，Vol.42Issue(3)：408-414,7.DOI:10.16190/j.cnki.45-1211/r.2025.03.011
血栓弹力图联合凝血功能检测预测妇科恶性肿瘤围手术期静脉血栓栓塞症的临床价值
The clinical value of thromboelastography combined with coagulation function tests in pre-dicting perioperative venous thromboembolism in gynecological malignant tumors
摘要
Abstract
Objective:To explore the clinical value of thromboelastography(TEG)combined with conventional coagulation function tests in predicting the occurrence of venous thromboembolism(VTE)in patients undergoing perioperative gynecologic malignant tumor.Methods:A total of 203 patients with gynecologic malignant tumors who underwent surgery in the Guangxi Medical University Cancer Hospital,Nanning from January 2021 to Janu-ary 2022 and met the inclusion criteria were selected.They were divided into a VTE group and a non-VTE group based on the occurrence of VTE after surgery.The differences in TEG and conventional coagulation function be-tween the two groups were compared,and binary logistic regression analysis was used to identify the high-risk factors for perioperative VTE in these patients.Receiver operating characteristic(ROC)curve analysis was also conducted to evaluate the value of TEG combined with conventional coagulation function tests in predicting VTE occurrence.Results:A total of 203 patients underwent surgery for gynecologic malignant tumors,and 30 cases of VTE occurred postoperatively,with an incidence of VTE being 14.8%.Multivariate analysis showed that patient age,AT3,and FIB were independent influencing factors for the occurrence of VTE during the perioperative pe-riod(P＜0.05).The ROC curve showed that the combined prediction of conventional coagulation function,thromboelastography,and age for postoperative VTE in patients had an area under the ROC curve(AUC)of 0.744,which was higher than that of single-item predictions as well as the combined prediction of conventional coagulation function and thromboelastography,with statistically significant differences(P＜0.05).The AUC of the combination of the R value,FIB,and D-dimer values in predicting the occurrence of VTE in patients after gy-necologic malignant tumor surgery was 0.664.Conclusion:The independent risk factors for the occurrence of VTE in patients undergoing gynecologic malignant tumor surgery during the perioperative period include patient age,AT3,FIB.The combination of age,conventional coagulation function,and thromboelastography can effec-tively predict the risk of VTE in gynecologic malignant tumor patients during the perioperative period.关键词
妇科恶性肿瘤/围手术期/静脉血栓栓塞症/血栓弹力图/凝血功能检测Key words
gynecological malignancy/perioperative period/venous thromboembolism/thromboelastogram/co-agulation function test分类
临床医学引用本文复制引用
吕益萍,陈良,鲍丽伊,王健理,李状,蔡志福,王鹤..血栓弹力图联合凝血功能检测预测妇科恶性肿瘤围手术期静脉血栓栓塞症的临床价值[J].广西医科大学学报,2025,42(3):408-414,7.基金项目
2021年区域性高发肿瘤早期防治研究重点实验室自主研究课题(No.GKE-ZZ 202147) （No.GKE-ZZ 202147）
广西第十八批"新世纪十百千人才工程"第二层次人选专项基金(No.2015226) （No.2015226）
广西医学高层次骨干人才培养"139"计划专项资金(No.G201903032) （No.G201903032）
