广西医科大学学报2025，Vol.42Issue(3)：420-426,7.DOI:10.16190/j.cnki.45-1211/r.2025.03.013
三酰甘油葡萄糖指数与颈动脉粥样硬化斑块的关联分析
Association analysis of the triglyceride-glucose index with carotid atherosclerotic plaques
摘要
Abstract
Objective:To investigate the association between the triglyceride-glucose(TyG)index and the occur-rence of carotid atherosclerotic plaque(CAP)in a population with varying characteristics.Methods:A total of 1,019 residents from Liuzhou City,Guangxi Zhuang Autonomous Region,who met the inclusion and exclusion criteria between 2019 and 2023,were selected as study participants.General data and laboratory biochemical indi-ces of the participants were collected,and they were categorized into 309 cases in the CAP group and 710 cases in the normal group based on carotid ultrasound results.The correlation between the TyG index and the occur-rence of CAP in the population with varying characteristics was analyzed using LASSO regression,multifactorial logistic regression,and linear trend tests.Results:LASSO regression identified eight variables to construct the subgroups for analysis:age,smoking,hypertension,low-density lipoprotein cholesterol(LDL-C),body mass in-dex(BMI),high-density lipoprotein cholesterol(HDL-C),sex,and drinking.Subgroup analysis results indicated an association between the TyG index and the occurrence of CAP in individuals under 60 years of age,those with drinking,and those who were overweight or obese.Furthermore,an interaction was observed between the TyG in-dex and factors such as drinking,overweight or obesity.The results of multivariate logistic regression showed that,after adjusting for confounders,the occurrence of CAP was 2.118 and 2.408 times higher at Level 3 and Level 4 of the TyG index,respectively,compared with the Level 1 of TyG index in overweight or obese popula-tions(P＜0.05).Moreover,the results of the linear trend test revealed a linear relationship between the TyG index and CAP(Ptrend＜0.05).Conclusion:There is a positive correlation between the TyG index and CAP among over-weight or obese individuals,suggesting that this group may be the key population for using the TyG index to evaluate the occurrence of CAP.关键词
颈动脉粥样硬化斑块/三酰甘油葡萄糖指数/超重或肥胖/LASSO回归Key words
carotid atherosclerotic plaque/triacylglycerol glucose index/overweight or obesity/LASSO regres-sion分类
临床医学引用本文复制引用
陈淑萍,唐薇婷,兰天,李锦隆,许琪,覃玲巧,钟秋安..三酰甘油葡萄糖指数与颈动脉粥样硬化斑块的关联分析[J].广西医科大学学报,2025,42(3):420-426,7.基金项目
国家自然科学基金资助项目(No.82060088) （No.82060088）
