广西医科大学学报2025，Vol.42Issue(3)：427-434,8.DOI:10.16190/j.cnki.45-1211/r.2025.03.014
端粒相关基因多态性对长寿人群血糖水平的影响
Influence of telomere-related gene polymorphisms on blood glucose levels in long-lived popu-lation
摘要
Abstract
Objectives:To explore the correlation between the telomere-related single nucleotide polymorphisms(SNPs)in TERC rs12696304,MYNN rs3772190 and LRRC31 rs16847897 and blood glucose levels in the long-lived population in Bama region of Guangxi.Methods:According to the fasting blood glucose levels,284 long-lived elderly people over 90 years old included in the analysis were divided into hyperglycemia group(59 cases)and normoglycemia group(225 cases).The TaqManMGB probe method was used to genotype the three men-tioned SNPs.Chi-square test and unconditional logistic regression analysis were used to evaluate the distributions of SNP genotypes and allele frequencies in the two groups as well as their relationships with blood glucose levels.Haploview 4.2 software was used to analyze the linkage disequilibrium(LD)between each locus,and haplotypes were constructed to understand the interaction between genes.The generalized multifactor dimensionality reduc-tion(GMDR)was used to further analyze the influence of gene-environment interaction on abnormal blood glu-cose levels.Results:There were statistically significant differences in the genotype and allele frequency distribu-tions of TERC rs12696304 and MYNN rs3772190 between the hyperglycemia group and the normoglycemia group(P＜0.05).For LRRC31 rs16847897,there was a statistically significant difference in the allele distribu-tions between the two groups(P＜0.05),while there was no statistically significant difference in the genotype dis-tribution(P=0.06).TERC rs12696304,MYNN rs3772190 and LRRC31 rs16847897 were all associated with the risk of hyperglycemia.The three loci of rs12696304,rs3772190,and rs16847897 were in a strong state of linkage disequilibrium.The distributions of haplotypes G-A-C and C-G-G were significantly different between the two groups(P＜0.05).There was an SNP-environment interaction between rs12696304 SNP and waist circumference(WC)(P=0.0107).The haplotype-environment interaction existed among C-G-G,C-G-C,TG and WC(P=0.0107).Conclusion:The telomere-related SNPs rs12696304,rs3772190 and rs16847897 are associated with el-evated fasting blood glucose levels in the long-lived population.Different interactions between SNPs,haplotypes,and the environment exhibit different effects on the risk of elevated blood glucose.关键词
端粒/单核苷酸多态性/空腹血糖/基因—环境交互作用/长寿Key words
telomere/single nucleotide polymorphism/fasting blood glucose/gene-environment interaction/lon-gevity分类
医药卫生引用本文复制引用
李佳,陈宁园,黄玲,潘尚领..端粒相关基因多态性对长寿人群血糖水平的影响[J].广西医科大学学报,2025,42(3):427-434,8.基金项目
国家自然科学基金资助项目(No.82360286) （No.82360286）
