广西医科大学学报2025，Vol.42Issue(3)：435-442,8.DOI:10.16190/j.cnki.45-1211/r.2025.03.015
广西某县农村人群老年营养风险指数与认知功能的关联性研究
Association between the geriatric nutritional risk index and cognitive function in the rural el-derly population of a county in Guangxi
摘要
Abstract
Objective:To investigate the relationship between the geriatric nutritional risk index(GNRI)and cog-nitive function among the rural residents aged 60 and above in a county of Guangxi,and further analyze the medi-ating role of high-density lipoprotein cholesterol(HDL-C)in this association.Methods:This study utilized data from the baseline cross-sectional survey of the Guangxi Environment and Health Middle-aged and Elderly Co-hort,with a final inclusion of 1,652 participants.The cognitive status of the participants was assessed using the mini-mental state examination(MMSE)questionnaire,and they were categorized into the cognitive impairment group and normal cognitive function group based on their MMSE scores and educational attainment.Multivari-able logistic regression analyses were performed to evaluate the association between the GNRI and cognitive function.A restricted cubic spline(RCS)model was constructed to analyze their nonlinear relationship.A media-tion model was subsequently conducted to investigate the intermediary role of HDL-C in this association.Re-sults:In this study,among the participants,325(19.67%)exhibited cognitive impairment.After adjusting for co-variates,compared with the lowest quartile of GNRI,the highest quartile of GNRI was significantly negatively correlated with the risk of cognitive impairment(OR=0.557,95%CI:0.382-0.813,P＜0.05).When the GNRI ex-ceeded 101.94,the risk of cognitive impairment in the elderly population showed a decreasing trend,and this trend was more pronounced in the female population.However,the mediation effect of HDL-C in the association between GNRI and cognitive function was not statistically significant.Conclusion:Higher GNRI levels are asso-ciated with a reduced risk of cognitive impairment,but HDL-C does not mediate this association.关键词
老年营养风险指数/认知功能/高密度脂蛋白胆固醇/中介作用Key words
geriatric nutritional risk index/cognitive function/high-density lipoprotein cholesterol/mediation ef-fect分类
医药卫生引用本文复制引用
滕开盛,官琴义,刘秋梅,蔡建升,李友,张志勇,覃健..广西某县农村人群老年营养风险指数与认知功能的关联性研究[J].广西医科大学学报,2025,42(3):435-442,8.基金项目
广西重大科技专项基金资助项目(No.AA22096026) （No.AA22096026）
国家自然科学基金资助项目(No.82260629 （）
No.82460629) （）
