广西医科大学学报2025，Vol.42Issue(3)：450-456,7.DOI:10.16190/j.cnki.45-1211/r.2025.03.017
中国中老年人不同胰岛素抵抗代替指标与新发2型糖尿病的关联分析
Association between different surrogate markers of insulin resistance and newly diagnosed type 2 diabetes mellitus among middle-aged and elderly people in China
摘要
Abstract
Objective:To explore the relationship between different surrogate markers of insulin resistance(IR)[Chinese visceral adiposity index(CVAI),lipid accumulation product(LAP),metabolic score for insulin resis-tance(METS-IR),metabolic score for visceral fat(METS-VF),triglyceride-glucose index(TyG)]and the inci-dence risk of type 2 diabetes mellitus(T2DM)among the middle-aged and elderly people in China.Methods:A total of 5,871 middle-aged and elderly individuals over 45 years old who participated in the China Health and Re-tirement Longitudinal Study from 2011 to 2015 were included as the research subjects.Logistic regression analy-sis was used to evaluate the association between different surrogate markers of IR and the incidence risk of T2DM.Additionally,the receiver operating characteristic(ROC)curve and the area under the curve(AUC)val-ues were used to evaluate the predictive ability of different markers for the incidence of T2DM among the middle-aged and elderly people.Results:All different surrogate markers of IR were positively correlated with the inci-dence risk of T2DM.After adjusting for all included covariates,the multivariate logistic regression analysis showed that the population in the highest group of CVAI(OR=1.91,95%CI:1.42-2.58),LAP(OR=2.06,95%CI:1.54-2.77),METS-IR(OR=2.28,95%CI:1.71-3.07),METS-VF(OR=2.01,95%CI:1.49-2.72),and TyG(OR=1.90,95%CI:1.41-2.58)had the highest incidence risk of T2DM.The AUC values of the five surrogate markers of IR ranged from 0.565 to 0.582.Among them,the AUC value of METS-VF was the highest(0.582,95%CI:0.569-0.595),and its predictive ability was METS-VF＞LAP＞CVAI＞TyG＞METS-IR.Conclusion:METS-IR has the strongest association with the incidence risk of T2DM,and METS-VF has the strongest efficacy in pre-dicting the onset of T2DM.Both of them have important clinical significance for the assessment and prediction of the incidence risk of T2DM among the middle-aged and elderly people in China,and can be used as reliable markers for targeted screening.关键词
2型糖尿病/内脏脂肪代谢分数/脂质蓄积指数/中国内脏肥胖指数/甘油三酯—葡萄糖指数/胰岛素抵抗代谢指数Key words
type 2 diabetes mellitus/metabolic score for visceral fat/lipid accumulation product/Chinese vis-ceral adiposity index/triglyceride-glucose index/metabolic score for insulin resistance分类
医药卫生引用本文复制引用
游蓉,李乐愚,徐瑞颜..中国中老年人不同胰岛素抵抗代替指标与新发2型糖尿病的关联分析[J].广西医科大学学报,2025,42(3):450-456,7.基金项目
广东省基础与应用基础研究基金项目(No.2022A1515011307) （No.2022A1515011307）
2024年广东省名中医传承工作室建设项目(中山卫健财[2024]9号) （中山卫健财[2024]9号）
