广西医科大学学报2025，Vol.42Issue(3)：471-474,4.DOI:10.16190/j.cnki.45-1211/r.2025.03.020
泛素特异性肽酶32在非小细胞肺癌中的功能作用研究
The functional role of USP32 in non-small cell lung cancer
摘要
Abstract
Non-small cell lung cancer(NSCLC),as the main histological subtype of lung cancer,has consis-tently ranked among the top malignant tumors in terms of incidence and mortality worldwide.With the advance-ment of high-throughput sequencing and proteomics technologies,the regulatory roles of deubiquitinating en-zymes(DUBs)family members in the pathological process of NSCLC have increasingly attracted attention.Nota-bly,ubiquitin-specific peptidase 32(USP32)possesses unique substrate recognition properties and multi-dimensional regulatory functions.It deeply participates in the pathological processes of malignant transformation,proliferation,invasion,and distant metastasis of NSCLC by coordinating the stability of key oncogenic proteins,maintaining genomic integrity,and remodeling the tumor microenvironment and other molecular pathways.This review systematically analyzes the molecular interaction network of USP32 in the occurrence and development of NSCLC,with a focus on clarifying its molecular mechanism of regulating tumor signal transduction through the ubiquitin-proteasome system,providing theoretical support for the development of innovative molecular targets and precise diagnosis and treatment strategies based on DUBs regulation.关键词
非小细胞肺癌/去泛素化酶/泛素特异性肽酶32/分子机制Key words
non-small cell lung cancer/deubiquitinating enzymes/ubiquitin-specific peptidase 32/molecular mechanism分类
医药卫生引用本文复制引用
柴桦,陈雯诗,农菲菲,幸尚平..泛素特异性肽酶32在非小细胞肺癌中的功能作用研究[J].广西医科大学学报,2025,42(3):471-474,4.基金项目
广西自然科学基金青年项目资助(No.2023GXNSFBA026237 （）
No.2025GXNSFBA069323) （）
国家自然科学基金资助项目(No.82460718) （No.82460718）
全国大学生创新创业训练计划项目资助(No.202410598025) （No.202410598025）
广西高校中青年教师基础科研能力提升项目资助(No.2023KY0308) （No.2023KY0308）
广西高校博士启动基金资助项目(No.2022BS033) （No.2022BS033）
广西青苗人才项目资助(No.DC2400003575) （No.DC2400003575）
