江汉大学学报（自然科学版）2025，Vol.53Issue(3)：56-65,10.DOI:10.16389/j.cnki.cn42-1737/n.2025.03.007
支原体肺炎患者细胞因子水平与肺泡灌洗液核酸检测结果的相关性分析
Correlation Between Cytokine Level and Nucleic Acid Detection Results of Alveolar Lavage Fluid in Patients with Mycoplasma Pneumonia
摘要
Abstract
Objective To explore the correlation between serum cytokine levels and clinical practice in patients with Mycoplasma pneumonia.Methods The clinical data of 40 patients with Mycoplasma pneumonia who were hospitalized at the Wuhan Hospital of Integrated Traditional Chinese and Western Medicine and underwent fiberoptic bronchoscopy from January 2023 to December 2023 were analyzed.The subjects were divided into a positive and a negative group based on the results of Mycoplasma nucleic acid detection in alveolar lavage fluid.The differences in various indicators between the two groups and the correlations between cytokine levels and those indicators were examined.Results The results showed that the average level of IL-2 in the positive group was higher than that in the negative group,the difference between the two groups was statistically significant(P<0.05),and the level of IL-2 was positively correlated with the detection results of Mycoplasma nucleic acid in alveolar lavage fluid(R>0,P<0.05).The levels of IL-2,IL-4,and INF-γ were positively correlated with length of stay(R>0,P<0.05).The levels of IL-6 and INF-γ were positively correlated with the consolidation of lung inflammation(R>0,P<0.05).The higher the levels of IL-6 and INF-γ,the easier the consolidation of lung inflammation was,and there was a positive correlation between INF-γ level and whether pleural effusion of patients(R>0,P<0.05).Conclusion The level of IL-2 can predict the detection of Mycoplasma nucleic acid in alveolar lavage fluid of patients with mycoplasmosis.IL-2,IL-4,IL-6,and INF-γ can be used as indicators to evaluate the severity of Mycoplasma pneumonia and provide an effective basis for clinical treatment and prognosis of Mycoplasma pneumonia.关键词
支原体肺炎/纤维支气管镜检查/细胞因子/肺泡灌洗术Key words
Mycoplasma pneumonia/fiberoptic bronchoscopy/cytokines/alveolar lavage分类
医药卫生引用本文复制引用
范思瑾,王爱利,罗丹..支原体肺炎患者细胞因子水平与肺泡灌洗液核酸检测结果的相关性分析[J].江汉大学学报（自然科学版）,2025,53(3):56-65,10.基金项目
湖北省自然科学基金项目(2024AFB1032) （2024AFB1032）
