神经损伤与功能重建2025，Vol.20Issue(6)：340-344,5.DOI:10.16780/j.cnki.sjssgncj.20230462
水凝胶搭载生长因子在脊髓损伤后不同阶段的研究进展
Research Progress on Hydrogel-Delivered Growth Factors in Different Stages After Spinal Cord Injury
郭宇恬 1龚芷宁 1高钰 1周敏 1张永杰2
作者信息
- 1. 南京医科大学第一临床医学院 南京 211166
- 2. 南京医科大学人体解剖学系 南京 211166
- 折叠
摘要
Abstract
Spinal cord injury(SCI)is a severe traumatic disease that has a profound impact on society,families,and patients.After SCI,neuronal axons exhibit limited spontaneous regenerative capacity,and effective clinical treatments remain lacking.Previous studies have demonstrated that various growth factors play crucial roles in protecting neural tissue,stimulating axonal regeneration and remyelination,and reducing scar formation after SCI.Hydrogels are currently considered ideal biomaterial scaffolds,as they can protect growth factors from deg-radation,enable localized delivery and sustained release of growth factors,and play significant roles in both the early phase and subsequent tissue regeneration stages after SCI.This article focuses on reviewing the research progress on hydrogel-delivered growth factor therapies for SCI during different stages of secondary damage and tissue regeneration.关键词
脊髓损伤/水凝胶/生长因子Key words
spinal cord injury/hydrogel/growth factors分类
临床医学引用本文复制引用
郭宇恬,龚芷宁,高钰,周敏,张永杰..水凝胶搭载生长因子在脊髓损伤后不同阶段的研究进展[J].神经损伤与功能重建,2025,20(6):340-344,5.
