华西口腔医学杂志2025，Vol.43Issue(3)：314-324,11.DOI:10.7518/hxkq.2025.2024427
口腔潜在恶性病变的临床病理学诊断研究进展
Progress in clinicopathological diagnosis of oral potentially malignant disorders
摘要
Abstract
As the field of oral pathology has evolved,the nomenclature and classification of oral mucosal diseases with a remarkable risk of malignant transformation have undergone several modifications.In 2005,the World Health Or-ganization(WHO)introduced the concept of oral poten-tially malignant disorders(OPMDs)as an alternative to the terms for oral precancerous lesions and precancerous conditions.In the consensus report by the WHO Collabo-rating Center for Oral Cancer of 2021,OPMD is defined as"any oral mucosal abnormality that is associated with a statistically increased risk of developing oral cancer."This definition encompasses a range of conditions,in-cluding oral leukoplakia,oral submucous fibrosis,proliferative verrucous leukoplakia,oral lichen planus,and other le-sions.In light of the complex etiology,unclear pathogenesis,and carcinogenesis of OPMDs,early and precise diagnosis and treatment can contribute to the secondary prevention of oral cancer.For this reason,this review,which aims to pro-vide a basis for the precise clinical diagnosis of OPMDs,was performed.Its aim was achieved by reviewing the histori-cal evolution and research progress of the nomenclature,classification,and histopathological diagnostic criteria of OP-MDs.关键词
口腔潜在恶性病变/口腔白斑/口腔黏膜下纤维性变/增殖性疣状白斑/口腔扁平苔藓Key words
oral potentially malignant disorders/oral leukoplakia/oral submucous fibrosis/proliferative verru-cous leukoplakia/oral lichen planus分类
口腔医学引用本文复制引用
崔莹莹,丁传扬,彭超然,张建运,蔡鑫嘉,李铁军..口腔潜在恶性病变的临床病理学诊断研究进展[J].华西口腔医学杂志,2025,43(3):314-324,11.基金项目
中国医学科学院口腔颌面部肿瘤精准病理诊断创新单元(2019-I2M-5-038) （2019-I2M-5-038）
国家资助博士后研究人员计划(GZB2024-0038) （GZB2024-0038）
北京慢性病防治与健康教育研究会、中关村人才协会医工领域"未来人才"培养计划(MBRC0012025013) Innovative Unit Project for Precise Pathological Diagnosis of Oral and Maxillofacial Tumors,Chinese Academy of Medical Sciences(2019-I2M-5-038) （MBRC0012025013）
Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZB20240038) （GZB20240038）
Beijing Research Association for Chronic Diseases Control and Health Education,Zhong-guancun Talent Association Medical Field"Future Talent"Training Program(MBRC0012025013) （MBRC0012025013）
