华西口腔医学杂志2025，Vol.43Issue(3)：354-361,8.DOI:10.7518/hxkq.2025.2024255
颞下颌关节紊乱病与失眠之间因果关系的两样本孟德尔随机化研究
A two-sample Mendelian randomization study on the association between temporomandibular disorder and in-somnia
摘要
Abstract
Objective This study aimed to investigate the association between temporomandibular disorder(TMD)and insomnia using a two-sample Mendelian randomization(MR)approach.Methods Bidirectional MR analyses of two samples,TMD(n=377 277)and insomnia(n=375 359),were performed using genome-wide association study sta-tistics published in the FinnGen database.Instrumental variables were first screened,and then inverse variance weight-ing(IVW)and MR-Egger were used as the main-effect assessment methods.Weighted median,weighted mode,and simple mode served as supplementary methods.We used IVW and MR-Egger to test for heterogeneity,as well as MR-Egger intercepts to assess the single nucleo-tide polymorphism(SNP)potential level of multiplicity effects.Sensitivity analyses were conducted based on leave-one-out to identify potentially influential SNPs.All analyses were conducted by using the two-sample MR R package and were considered statistically significant when P＜0.05.Results MR analysis showed the presence of TMD on insomnia(OR=1.089,95％CI:1.017-1.166,P=0.014).Meanwhile,no effect of insomnia on TMD(OR=0.996,95％CI:0.964-1.029,P=0.816)was found.The sensitivity-analysis showed that no heterogeneity existed(P＞0.05),and the presence of horizontal pleiotropy was not detected(P＞0.05).Leave-one-out sensitivity analysis showed no single SNP,which may affect the causal relation.All findings indicated that the causal relationship be-tween TMD and insomnia was not significantly affected by any individual SNP and that Ⅳ did not bias the results.Conclusion Results of MR analyses showed that TMD is a risk factor for insomnia,whereas insomnia is not a risk factor for TMD.关键词
颞下颌关节紊乱病/失眠/孟德尔随机化/全基因组关联研究/风险因素Key words
temporomandibular disorder/insomnia/Mendelian randomization/genome-wide association study/risk factors分类
口腔医学引用本文复制引用
袁玮,程一茗,崔蕴熠,高朵朵..颞下颌关节紊乱病与失眠之间因果关系的两样本孟德尔随机化研究[J].华西口腔医学杂志,2025,43(3):354-361,8.基金项目
邯郸市科学技术研究与发展计划(23422083074ZC) Handan Science and Technology Research and Development Plan Project(23422083074ZC) （23422083074ZC）
