刘恩言 1段丁瑜 1谢旭东 1李灏来 2李茂雪 1丁一1
作者信息
- 1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周病科,成都 610041
- 2. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心 四川大学华西口腔医院国家药物/医疗器械临床试验机构,成都 610041
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摘要
Abstract
Objective This study aimed to evaluate the therapeutic effect of 1％povidone-iodine mouthwash com-bined with scaling and root planing in patients with stage Ⅰ/Ⅱ class A/B periodontitis,and to provide a basis for the clinical application of povidone-iodine mouthwash.Methods Seventy-five subjects were included in this trial and ran-domly divided into three groups.After full-mouth ultra-sonic supragingival cleansing,scaling and root planing,the placebo group was treated with sodium chloride injec-tion(NaCl group),the control group was treated with compound chlorhexidine mouthwash(CHX group),and the experi-mental group was treated with 1％povidone-iodine mouthwash(PVP-I group),and rinsed their mouths for 1 week,re-spectively.Subjects were tested at 1,4,and 12 weeks after dosing for clinical indicators,microbial composition of supra-gingival plaque,gingival crevicular fluid inflammatory marker levels,and patient-reported outcomes.Results Sixty-three subjects completed the follow-up.After treatment,the clinical indicators,microbial indicators,and inflammatory in-dicators were all significantly improved(P＜0.05).Comparisons among the groups showed that one week after treatment,the bleeding index and plaque index of the CHX group and the PVP-I group were lower than those of the NaCl group,and the plaque index of the CHX group was lower than that of the PVP-I group(P＜0.05).There were no statistically sig-nificant differences in the other clinical indicators among the groups(P＞0.05).Twelve weeks after treatment,the Shan-non index of the CHX group was lower than that of the NaCl group(P＜0.05),and there were no statistically significant differences in the other microbial indicators among the groups(P＞0.05).Twelve weeks after treatment,the interleukin-10 concentration of the CHX group was higher than that of the NaCl group(P＜0.05),and there were no statistically signifi-cant differences in the other inflammatory indicators among the groups(P＞0.05).The PVP-I group had the highest scores in terms of taste and oral odor.There was no obvious staining on the tooth surfaces and mucosa in all three groups.Conclusion 1％PVP-I mouthwash combined with scaling and root planing can effectively reduce gingival in-flammation and dental plaque,improve clinical symptoms in the short term.While its efficacy is not significantly inferior to that of chlorhexidine,PVP-I mouthwash is more acceptable to patients than chlorhexidine.关键词
牙周基础治疗/龈下刮治与根面平整术/聚维酮碘/龈上菌斑/龈沟液Key words
initial periodontal therapy/scaling and root planing/povidone-iodine/supragingival plaque/gin-gival crevicular fluid分类
口腔医学
