军事医学2025，Vol.49Issue(5)：364-369,6.DOI:10.7644/j.issn.1674-9960.2025.05.006
祛寒通络方联合塞来昔布治疗膝骨关节炎的临床研究
Clinical efficacy of Quhan Tongluo Formula combined with celecoxib against knee osteoarthritis
摘要
Abstract
Objective To investigate the clinical efficacy and safety of Quhan Tongluo Formula in treating knee osteoarthritis(KOA)of cold-dampness obstruction pattern.Methods A retrospective study was conducted on 231 patients with KOA of cold-dampness obstruction pattern admitted to Dongfang Hospital,Beijing University of Chinese Medicine from December 2022 to December 2023.The patients were divided into an exposed group(105 cases)and a non-exposed group(126 cases)based on whether Quhan Tongluo Formula was applied.The exposed group received Quhan Tongluo Formula combined with celecoxib,while the non-exposed group received only celecoxib.Using propensity score matching based on the baseline data of the medical records,76 pairs(a total of 152 cases)were matched.The changes in Visual Analog Scale(VAS)scores,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)total scores,and traditional Chinese medicine(TCM)syndrome scores before treatment and at 2,4,and 6 weeks after treatment were compared between the two groups,and safety was evaluated.Results Before treatment,there were no significant differences in VAS scores or WOMAC pain scores between the two groups.After treatment,both groups exhibited significant reductions in VAS scores and WOMAC pain scores,with the exposed group demonstrating significantly greater reductions compared to the non-exposed group(P＜0.01).The total clinical effective rate was significantly higher in the exposed group than in the non-exposed group(P＜0.01).Conclusion The clinical application of Quhan Tongluo Formula combined with celecoxib demonstrated superior efficacy over celecoxib monotherapy in treating knee osteoarthritis of cold-dampness obstruction pattern.The combined regimen significantly reduced VAS scores,total WOMAC scores,and TCM syndrome scores,with marked improvements in long-term efficacy.关键词
祛寒通络方/膝骨关节炎/回顾性研究Key words
Quhan Tongluo formula/knee osteoarthritis/retrospective cohort study分类
中医学引用本文复制引用
张振华,黄江海,王亚非,李运海..祛寒通络方联合塞来昔布治疗膝骨关节炎的临床研究[J].军事医学,2025,49(5):364-369,6.基金项目
北京市自然科学基金项目(7174317) （7174317）
北京中医药大学基本科研业务费项目(2019-JYB-JS-101) （2019-JYB-JS-101）
