国际眼科杂志2025，Vol.25Issue(7)：1062-1066,5.DOI:10.3980/j.issn.1672-5123.2025.7.04
3％地夸磷索钠滴眼液在青少年角膜塑形镜早期配戴中对轻度干眼的治疗
Efficacy of 3％diquafosol sodium eye drops in adolescents with mild dry eye during early stage of wearing orthokeratology lenses
摘要
Abstract
AIM:To evaluate the effects of 3％diquafosol ophthalmic solution(DQS)on the ocular surface and tear film in adolescents with mild dry eye syndrome during the early stage of wearing orthokeratology lenses. METHODS:Prospective study.Totally 60 myopic adolescents(120 eyes)with mild dry eye syndrome who were fitted with orthokeratology lenses for the first time in our hospital from January 2023 to September 2023 were enrolled in this study.They were randomly divided into control group and observation group.Both groups wore the same brand of orthokeratology lenses for 8-9 h a day and 7 d a week.In the control group(30 cases,60 eyes),the patients were treated by routine eyelid cleaning and warm compresses from the day of fitting.In addition to the control group's treatment,patients in the observation group(30 cases,60 eyes)were given DQS 6 times a day for 3 mo,and follow-up for 6 mo after discontinuation of DQS.According to the follow-up requirements of orthokeratology lens,uncorrected visual acuity(UCVA),corneal curvature,corneal topography,and corneal fluorescein staining were rechecked.The ocular surface disease index(OSDI)scores,tear meniscus height(TMH)of lower eyelid,non-invasive tear film break-up time[first and average,NIBUT(f)and NIBUT(av)]and corneal fluorescein staining were measured at baseline,1,2 and 3 mo after treatment,and 3 and 6 mo after DQS discontinuation. RESULTS:All patients completed follow-up.The NIBUT(f),NIBUT(av)and TMH of lower eyelid in the observation group were higher than those in the control group at 2 and 3 mo after treatment and at 3 and 6 mo after discontinuation of DQ3(all P＜0.05).The OSDI scores for both groups decreased significantly at 2 mo after treatment(all P＜0.05).At 3 mo after treatment and 3 and 6 mo after discontinuation of DQS,the OSDI scores in the observation group was significantly lower than the control group(all P＜0.01).There was no significant difference of corneal fluorescein staining between the two groups(P=0.731). CONCLUSION:The combination of DQS with eyelid hygiene and warm compresses shows better efficacy in enhancing the stability of the tear film for adolescents with mild dry eye syndrome while wearing orthokeratology lenses.关键词
地夸磷索钠滴眼液/角膜塑形镜/轻度干眼/近视Key words
diquafosol ophthalmic solution/orthokeratology lens/mild dry eye/myopia引用本文复制引用
付勇,谢永鑫,韩海涛,刘懋..3％地夸磷索钠滴眼液在青少年角膜塑形镜早期配戴中对轻度干眼的治疗[J].国际眼科杂志,2025,25(7):1062-1066,5.基金项目
潍坊市科技发展计划项目(No.2022YX064) Science and Technology Development Plan Project of Weifang City(No.2022YX064) （No.2022YX064）
