军事医学2025，Vol.49Issue(5)：396-400,5.DOI:10.7644/j.issn.1674-9960.2025.05.012
α2-巨球蛋白的分子机制研究进展
Research progress in the molecular mechanism of α2-macroglobulin
摘要
Abstract
α2-Macroglobulin(A2M)is a high-abundance plasma protein with a molecular weight of 720×103,containing 1451 residues and 11 domains,and was isolated and identified for the first time in 1946.The capture and inhibitory effect on proteases is the classical biological function of A2M.However,A2M can also interact with membrane receptors,cytokines,and growth factors,and act as a molecular chaperone to affect extracellular protein homeostasis so that it is involved in a wide range of physiological and pathological processes such as immunity,inflammation,and degeneration.This article reviews the structural characteristics of A2M,the reported molecular targets,the mechanism of action,and its biological effects in the hope of providing a new line of thought for the functional exploration and clinical applications of A2M.关键词
α2-巨球蛋白/蛋白酶/低密度脂蛋白受体相关蛋白1/细胞外分子伴侣/血浆蛋白制品Key words
α2-macroglobulin/protease/low-density lipoprotein receptor-related protein 1/extracellular molecular chaperone/plasma protein product分类
医药卫生引用本文复制引用
袁方,贾俊婷,马玉媛..α2-巨球蛋白的分子机制研究进展[J].军事医学,2025,49(5):396-400,5.基金项目
北京市科技计划项目(Z221100007922031) （Z221100007922031）
北京市自然科学基金项目(7244471) （7244471）
