农业生物技术学报2025，Vol.33Issue(7)：1636-1644,9.DOI:10.3969/j.issn.1674-7968.2025.07.019
奶牛乳腺上皮细胞中调控乳蛋白合成的mTOR信号通路
The mTOR Signaling Pathway Regulating Milk Protein Synthesis in Mammary Epithelial Cells of Dairy Cows(Bos taurus)
摘要
Abstract
Mammalian target of rapamycin(mTOR)is an evolutionarily conserved serine/threonine protein kinase with important regulatory roles in cell growth and many biosynthetic and catabolic processes,especially in mammary casein synthesis.mTOR signaling pathway plays a key role in determining milk yield and quality.Amino acids can be used as signaling molecules to promote the phosphorylation of the mTOR signaling pathway and regulate the synthesis of milk proteins in mammary epithelial cells of dairy cows(Bos taurus).This paper focuses on the structure and function of the mTOR signaling pathway in mammary cells,and reveals the amino acid sensing system of mTOR signaling in the regulation of milk protein synthesis in the light of the progress of related research,with a view to providing reference for further optimizing the amino acid nutrition of dairy cows,improving the efficiency of amino acid utilization,and then improving the yield and quality of cow milk.关键词
哺乳动物雷帕霉素靶蛋白C1(mTORC1)/氨基酸感受器/乳蛋白合成/乳腺Key words
Mammalian target of rapamycin C1(mTORC1)/Amino acid sensor/Milk protein synthesis/Mammary gland分类
畜牧业引用本文复制引用
杨松桦,杜瑞芳,高远大,李飞,郭龙..奶牛乳腺上皮细胞中调控乳蛋白合成的mTOR信号通路[J].农业生物技术学报,2025,33(7):1636-1644,9.基金项目
甘肃省科技计划项目(22YF7WA011 （）
23JRRA1078 （）
20JR10RA642) （）
国家自然科学基金(32002167) （32002167）
国家重点研发计划(2022YFD1602201) （2022YFD1602201）
金昌市重点科技计划项目(2024JC00152) （2024JC00152）
