临床神经外科杂志2025，Vol.22Issue(3)：248-252,258,6.DOI:10.3969/j.issn.1672-7770.2025.03.002
丘脑底核电刺激术治疗帕金森病前瞻性研究及丘脑底核有效刺激体积与疗效的相关性研究
Prospective study of subthalamic nucleus electrical stimulation for Parkinson's disease and the correlation between effective stimulation volume of subthalamic nucleus and curative effect
摘要
Abstract
Objective To evaluate the efficacy and safety of subthalamic nucleus(STN)deep brain stimulation(DBS)under general anesthesia in the treatment of Parkinson's disease(PD).The correlation between STN and to analyze subregion effective volume of tissue activated(VTA)and clinical symptoms.Methods A total of 40 patients with PD who underwent bilateral STN DBS surgery in the Department of Neurosurgery,Nanchong Central Hospital from January 2024 to June 2024 were collected.The clinical efficacy of patients in terms of movement(UPDRS-Ⅲ),anxiety(HAMA),depression(HAMD),cognition(MoCA),quality of life(PDQ-39),etc were analyzed before surgery and three months after surgery.The Lead DBS software was used to reconstruct the electrodes,contacts and implanted target nuclei and subregions,and STN and subregion VTA could be accurately calculated,and the correlation between STN and subregion VTA and the preoperative and postoperative changes in clinical symptoms can be analyzed.Results At the follow-up 3 months after surgery,UPDRS-Ⅲ,HAMA and HAMD were significantly decreased(P=0.035),MoCA was not significantly decreased(P=0.078),and PDQ-39 was significantly decreased(P＜0.001).LEDD decreased significantly(P＜0.001).Correlation analysis showed that the change of UPDRS-Ⅲ score was significantly positively correlated with total STN-VTA(r=0.607,P＜0.001)and STN motor-VTA(r=0.587,P＜0.001).There was a significant positive correlation between life quality score and STN motor-VTA(r=0.612,P=0.025).Conclusions STN DBS can significantly improve the motor symptoms,anxiety and depression of PD patients,improve the quality of life,reduce the amount of medication,and have little impact on cognitive function.Lead DBS can be used as one of the auxiliary means of postoperative visual precision program control for STN DBS in PD.关键词
帕金森病/脑深部电刺激/丘脑底核/全麻/有效刺激体积Key words
Parkinson's disease/deep brain stimulation/subthalamic nucleus/general anesthesia/volume of tissue activated分类
临床医学引用本文复制引用
任海波,王林,陈兵,罗波,杨荣,何秋果,刘毅..丘脑底核电刺激术治疗帕金森病前瞻性研究及丘脑底核有效刺激体积与疗效的相关性研究[J].临床神经外科杂志,2025,22(3):248-252,258,6.基金项目
国家卫生健康委能力建设和继续教育中心(W2024SNKT17) （W2024SNKT17）
南充市市校科技战略合作项目(22SXQT0042) （22SXQT0042）
