临床神经外科杂志2025，Vol.22Issue(3)：263-270,277,9.DOI:10.3969/j.issn.1672-7770.2025.03.005
原发性Meige综合征不同靶点脑深部电刺激疗效比较
Comparison of efficacy of deep brain stimulation with different targets in primary Meige syndrome
摘要
Abstract
Objective To compare the efficacy of deep brain stimulation(DBS)with different targets in primary Meige syndrome(PMS).Methods The clinical data of 15 patients with PMS underwent DBS treatment targeting different sites in the Department of Neurosurgery,the First Affiliated Hospital of Xinjiang Medical University from April 2021 to June 2024 were analyzed retrospectively.The 15 patients with PMS received bilateral subthalamic nucleus(STN)or globus pallidus internus(GPi)DBS surgery.The Burke-Fahn-Marsden Dystonia Rating Scale(BFMDRS)(including motor and disability subscale),Hamilton Anxiety Scale(HAMA),and Hamilton Depression Scale(HAMD)were uniformly used to evaluate and record the preoperative and postoperative muscle tone,limb motor function,and mental status of the enrolled patients,as well as to document the related postoperative complications.Results The average improvement rate of BFMDRS was 59.23％in 15 patients at 3 months after surgery,and 67.87％in 10 patients at 12 months after surgery,respectively.The average improvement rates of motor scores between patients who received GPi stimulation and STN stimulation were 65.80％and 71.70％,respectively,and the stimulation of the two targets could effectively improve the symptoms,but without statistical difference(P＞0.05).The scores of HAMA scale and HAMD scale were improved to different extent compared with those before operation,and the improvement rate of HAMA scale in the STN group was better than that in the GPi group with statistical significance(P＜0.05).Conclusions Both DBS targets are safe and effective in improving motor symptoms in patients with Meige syndrome,and there is no significant difference between two DBS targets for symptom improvement,and STN-DBS and anxiety symptoms improved better than GPi-DBS.关键词
Meige综合征/苍白球内侧部/丘脑底核/脑深部电刺激/焦虑/抑郁Key words
Meige syndrome/globus pallidus internus/subthalamic nucleus/deep brain stimulation/anxiety/depression分类
临床医学引用本文复制引用
吴海龙,非尔凯提·阿不都克依木,裴祎楠,冯兆海,姜磊..原发性Meige综合征不同靶点脑深部电刺激疗效比较[J].临床神经外科杂志,2025,22(3):263-270,277,9.基金项目
中央引导地方科技发展专项资金项目(2YYD2022A04) （2YYD2022A04）
