山东农业大学学报（自然科学版）2025，Vol.56Issue(3)：486-494,9.DOI:10.3969/j.issn.1000-2324.2025.03.013
基于止血效果综合评价模型探究白地汤对小鼠止血功能的影响
Hemostatic Effects of Baidi Decoction in Mice Based on a Comprehensive Hemostasis Assessment Model
摘要
Abstract
To investigate the hemostatic effects of different ratio formulations of Baidi decoction and explore its hemostatic mechanism,this study establishes an efficacy evaluation and screening model for hemostatic traditional Chinese medicines and evaluates the hemostatic effect of Baidi decoction based on this model.The study selects six indicators,including Platelet(PLT)count,Bleeding Time(BT),Prothrombin Time(PT),Activated Partial Thromboplastin Time(APTT),Thrombin Time(TT)and Fibrinogen(FIB),to establish a comprehensive hemostasis evaluation model by combining analytic hierarchy process with a"radar chart"pattern.ICR mice are used to compare the hemostatic effects of normal saline,Yunnanbaiyao,Baitouweng-Diyutan 2:1(referred to as Baidi decoction 2:1),Baidi decoction 3:2,Baidi decoction 1:1,Baitouweng and Diyutan.The results show that all three ratios of Baidi decoction,Diyutan have hemostatic effects.Among them,all Baidi decoction groups shorten BT,APTT,TT while increasing FIB;Diyutan group shorten BT,APTT,PT while increasing FIB,but it has no effect on TT;Only Diyutantan and Baidi decoction 1:1 increase total PLT count.In contrast,Baitouweng is less effective in stopping bleeding and only shorten TT.According to the comprehensive evaluation model for hemostatic effects,the seven samples rank as follows:Baidi decoction 1:1>Yunnanbaiyao>Diyutan>Baidi decoction 2:1>Baidi decoction 3:2>Baitouweng>Saline.These findings indicate that Baidi decoction has both hemostatic and coagulant properties,and the effect of stopping bleeding changes after the pairing of Diyutan and Baitouweng,with the 1:1 ratio demonstrating the optimal efficacy.This result provides a foundation for the treatment of hemorrhagic diseases in animals and the development of related hemostatic veterinary drugs.关键词
"蛛网"模式/层次分析法/白地汤/止血/小鼠Key words
"Radar chart"pattern/analytic hierarchy process/Baidi decoction/hemostasis/mice分类
农业科技引用本文复制引用
衣兰晓,张丽,李灿欣,盛伊果,张永贤,徐在品,姚碧琼..基于止血效果综合评价模型探究白地汤对小鼠止血功能的影响[J].山东农业大学学报（自然科学版）,2025,56(3):486-494,9.基金项目
国家自然科学基金地区基金资助项目(11862004) （11862004）
黔科合平台人才基金资助项目([2018]5781) （[2018]5781）
