临床神经外科杂志2025，Vol.22Issue(3)：330-333,339,5.DOI:10.3969/j.issn.1672-7770.2025.03.016
PTX3调节胶质瘤TMZ耐药的研究进展
Research progress on PTX3 regulation of glioma temozolomide resistance
摘要
Abstract
Glioblastoma(GBM)is one of the most aggressive and lethal malignancies within the central nervous system,with therapeutic efficacy often limited by the development of resistance.Temozolomide(TMZ)is the cornerstone chemotherapeutic agent in the standard treatment regimen for GBM.However,the emergence of TMZ resistance significantly impacts patient survival outcomes.In recent years,Pentraxin 3(PTX3),a key regulatory factor within the tumor microenvironment(TME),has garnered widespread attention for its role in the development of resistance in GBM.PTX3 not only promotes tumor survival and invasion by modulating immune cell polarization,redox balance,and the inhibition of autophagy within the TME,but also enhance the resistance of tumor cells to TMZ through interactions with multiple cellular signaling pathways.This review discusses the specific role of PTX3 in the mechanisms of GBM resistance and explores its potential as a therapeutic target,aiming to provide new strategies and insights for overcoming GBM resistance.关键词
胶质母细胞瘤/Pentraxin3(PTX3)/肿瘤微环境/耐药机制/氧化还原平衡/细胞自噬抑制调控Key words
glioblastoma/Pentraxin 3/tumor microenvironment/resistance mechanisms/redox balance/regulation of autophagy inhibition分类
医药卫生引用本文复制引用
李阳洋,金朝晖,汤磊,王冉,杨坤..PTX3调节胶质瘤TMZ耐药的研究进展[J].临床神经外科杂志,2025,22(3):330-333,339,5.基金项目
江苏省研究生实践创新计划项目(SJCX22_0667) （SJCX22_0667）
南京市医学科技发展重点项目(ZKX22041) （ZKX22041）
