曲阜师范大学学报（自然科学版）2025，Vol.51Issue(3)：91-98,8.DOI:10.3969/j.issn.1001-5337.2025.3.091
基于高分子胶束增溶Kartogenin的天然多糖水凝胶
Improved solubilization of Kartogenin in natural polysaccharide hydrogel through polymer micelles
摘要
Abstract
In order to solve the problem of low solubility of hydrophobic drug Kartogenin(KGN)in hydrogel,shell crosslinked F127 micelles was synthesized to dissolve KGN,followed by adding into hydro-gels.Based on the hydrophobicity of middle block polyepoxypropane of F127 and the hydrophobicity of KGN,the efficient loading of KGN in shell crosslinked F127 micelles was realized.At the same time,natu-ral polysaccharide based hydrogel was prepared by Schiff base crosslinking between hydroxypropyl chitosan(HPCS)and oxidized konjac glucomannan(OKGM).The optimal ratio of HPCS and OKGM was obtained through rheological experiments and morphological characterization,and the shell crosslinked F127 mi-celles loaded with KGN was used as the addition component of the hydrogel.In this work,the hydrogel loading of hydrophobic drug KGN is realized,which provides a method to improve the hydrogel loading of hydrophobic drug molecules.关键词
泊洛沙姆F127/胶束/水凝胶/天然多糖Key words
Poloxamer F127/micelle/hydrogel/natural polysaccharides分类
化学化工引用本文复制引用
白啸,柴娟,尹航,吕春燕,刘哲..基于高分子胶束增溶Kartogenin的天然多糖水凝胶[J].曲阜师范大学学报（自然科学版）,2025,51(3):91-98,8.基金项目
山东省自然科学基金(ZR2019PEM002). （ZR2019PEM002）
