世界科学技术-中医药现代化2025，Vol.27Issue(6)：1780-1785,6.DOI:10.11842/wst.20240814003
从调控星形胶质细胞角度探讨中药治疗阿尔茨海默病的机制
Exploration of the Mechanism of Traditional Chinese Medicine in the Treatment of Alzheimer's Disease from the Perspective of Regulating Astrocytes
摘要
Abstract
Alzheimer's disease(AD),a common geriatric ailment,exerts a severe impact on people's lives.Traditional Chinese medicine(TCM)demonstrates a favorable effect on the intervention of AD,while the mechanism remains in the exploratory phase.Recent studies have indicated that astrocytes play a significant role in AD.The mechanism of TCM in the treatment of AD from the perspective of astrocyte regulation was explored,and the roles of astrocytes in the pathogenesis of AD was summarized,namely maintaining energy metabolism,regulating synaptic plasticity,and mediating inflammatory responses,thereby providing a TCM-based solution with a clear mechanism for clinical and scientific intervention in AD.关键词
阿尔茨海默症/星形胶质细胞/能量代谢/突触可塑性/神经炎症Key words
Alzheimer's disease/Astrocytes/Energy metabolism/Synaptic plasticity/Neuroinflammation分类
医药卫生引用本文复制引用
张子冉,胡孜维,田会玲..从调控星形胶质细胞角度探讨中药治疗阿尔茨海默病的机制[J].世界科学技术-中医药现代化,2025,27(6):1780-1785,6.基金项目
北京市教育委员会科技计划一般项目(KM202410025020):基于星形胶质细胞清除DNs探讨针刺改善AD小鼠认知水平的机制,负责人:田会玲. （KM202410025020）
