世界科学技术-中医药现代化2025，Vol.27Issue(6)：1786-1794,9.DOI:10.11842/wst.20240729005
线粒体氧化磷酸化结合中医药在心血管疾病中的研究
Research on Combination of Mitochondrial Oxidative Phosphorylation and Traditional Chinese Medicine in Cardiovascular Diseases
摘要
Abstract
Mitochondria are widely involved in the important pathophysiological processes such as cell apoptosis,metabolism,immune response,and signal transduction,and are the central hub of energy metabolism in most eukaryotic cells.Oxidative phosphorylation(OXPHOS)is a key link in mitochondrial adenosine triphosphate(ATP)production for energy supply.Mitochondria provide potential energy through an electron transport chain,which generates a proton gradient in the mitochondrial inner membrane and reacts with complex ATPase to produce ATP.Ischemia,hypoxia,and other factors can cause mitochondrial damage,imbalance of OXPHOS,leading to myocardial energy deficiency,oxidative stress damage,cell apoptosis,and other important mechanisms in the occurrence and development of cardiovascular diseases.Traditional Chinese medicine has a definite therapeutic effect on improving cardiovascular diseases,and its mechanism may be closely related to regulating mitochondrial OXPHOS and reducing structural and functional damage to myocardial cells.Based on this,the mechanism of mitochondrial OXPHOS in cardiovascular diseases and the intervention effect of traditional Chinese medicine were systematically reviewed to provide a basis for clinical treatment of cardiovascular diseases.关键词
线粒体氧化磷酸化/心血管疾病/能量代谢/中医药Key words
Mitochondrial oxidative phosphorylation/Cardiovascular disease/Energy metabolism/Traditional Chinese medicine分类
医药卫生引用本文复制引用
张泸丹,王新陆,朱明军,赵齐飞..线粒体氧化磷酸化结合中医药在心血管疾病中的研究[J].世界科学技术-中医药现代化,2025,27(6):1786-1794,9.基金项目
国家自然科学基金委员会青年科学基金项目(82004343):基于miR-199a-5p/Sirt1/irt3轴调控的线粒体质量控制探讨芪苈强心胶囊干预CHF心肌能量代谢的作用机制,负责人:赵齐飞. （82004343）
