生命科学仪器2025，Vol.23Issue(3)：131-133,3.DOI:10.11967/2025230644
Tim-3调控巨噬细胞极化在IgG4相关性疾病中的研究进展
Research Progress of Tim-3 Regulating Macrophage Polarization in IgG4-Related Diseases
摘要
Abstract
IgG4-related disease(IgG4-RD)is a rare immune-mediated multi-organ inflammatory disease,which often involves some gland tissues,especially salivary glands.T cell immunoglobulin mucin molecule-3(Tim-3)is a negative immunoregulatory costimulatory molecule mainly expressed on T cells of the immune system,and its signal transduction can regulate the immune response of macrophages.Many studies have shown that Tim-3 plays a key role in the immune response,which can regulate macrophage polarization and mediate immune response,and is of great significance in the pathological process of IgG4-RD.Therefore,this article reviews the immune mechanism of Tim-3 regulating macrophage phenotypic polarization in IgG4-RD,and provides new ideas for the clinical research of IgG4-RD.关键词
IgG4相关性疾病/巨噬细胞/Tim-3/巨噬细胞极化Key words
IgG4-related diseases/Macrophages/Tim-3/Macrophage polarization.分类
医药卫生引用本文复制引用
岳蓉蓉,龚忠诚..Tim-3调控巨噬细胞极化在IgG4相关性疾病中的研究进展[J].生命科学仪器,2025,23(3):131-133,3.基金项目
新疆维吾尔自治区自然科学基金面上项目(2022D01C482) （2022D01C482）
