生物技术通报2025，Vol.41Issue(6)：12-26,15.DOI:10.13560/j.cnki.biotech.bull.1985.2025-0056
RNA结合蛋白在植物抗病中的研究进展
Research Progress in RNA Binding Proteins in Plant Disease Resistance
摘要
Abstract
During their growth and development,plants are continuously exposed to complex environmental stresses that severely constrain their growth,agronomic traits,and productivity.To combat biotic stresses such as pathogen infection,plants have evolved multilayered sophisticated regulatory networks.In recent years,post-transcriptional regulation has emerged as a novel research hotspot in plant immunity,demonstrating unique advantages in the resistance to disease through dynamic regulation of messenger RNA(mRNA)metabolism.RNA-binding proteins(RBPs),functioning as core executors in plant resistance-to-resistane networks,act as"molecular switches"in plant-pathogen interactions by recognizing specific RNA motifs to regulate critical processes including pre-mRNA alternative splicing,mRNA stability,alternative polyadenylation(APA),translation efficiency,and RNA modifications.This review systematically elaborates RBP-mediated post-transcriptional regulatory mechanisms and their functions during plant-pathogen interactions.For instance,at the pathogen-recogned stage,RBPs regulate mRNA stability of immune receptors to enable rapid activation of defense signals.During disease resistance responses,RBPs mediate alternative splicing of resistance genes to generate transcript variants with distinct subcellular localization or functional activities.Recent studies also reveal novel pathways in plant immunity where RNA epigenetic modifications(e.g.,m6A)regulate RBP recruitment efficiency.This article provides in-depth analysis of the multilayered defense systems constructed through RBPs and their molecular regulatory mechanisms,while proposing future research directions including deciphering RBP-mediated disease resistance mechanisms,modifying RBP regulatory elements through multi-omics integration,and developing novel disease-resistant breeding strategies.Comprehensive understanding of RNA regulatory codes in plant immunity will offer theoretical foundations for creating broad-spectrum resistant germplasm and provide crucial references for developing innovative green control strategies.关键词
RNA结合蛋白/选择性剪接/翻译/mRNA稳定性/选择性多聚腺苷酸化Key words
RNA binding protein/alternative splicing/translation/mRNA stability/alternative polyadenylation引用本文复制引用
吕悦,张杰伟,王勃..RNA结合蛋白在植物抗病中的研究进展[J].生物技术通报,2025,41(6):12-26,15.基金项目
北京市农林科学院科技创新能力建设专项(KJCX20230120,KJCX20230203),烟台大学研究生科研创新基金资助(KGIFYTU2411),小麦育种全国重点实验室开放课题2025 （KJCX20230120,KJCX20230203）
