实用医学杂志2025，Vol.41Issue(12)：1873-1878,6.DOI:10.3969/j.issn.1006-5725.2025.12.015
涎腺腺样囊性癌组织色素框同源蛋白2、T细胞免疫球蛋白黏液素3表达水平及与患者临床病理特征、预后的关系
The levels of CBX2 and TIM3 in salivary adenoid cystic carcinoma tissue and their relationship with clinical pathological features and prognosis
摘要
Abstract
Objective To investigate CBX2 and TIM3 in salivary adenoid cystic carcinoma(SACC)tissue and their relationship with clinical pathological features and prognosis.Methods 80 patients with SACC who underwent surgical treatment in the First Affiliated Hospital of Hebei North University from January 2016 to January 2020 were selected.Immunohistochemistry was used to measure CBX2 and TIM3 in tissues.The relationship between CBX2 and TIM3 in SACC tissue and prognosis was discussed though Kaplan-Meier method.The factors influencing the prognosis of SACC were discussed using multivariate Cox regression.Results The positive rates of CBX2 and TIM3 in SACC tissues were clearly higher than those in normal glandular tissues adjacent to cancer(χ2=11.237,8.229,P<0.05).The CBX2 and TIM3 were associated with nerve invasion and distant metastasis(P<0.05).After a 5-year follow-up,26 cases died and 54 cases survived,with an overall 5-year survival rate of 67.50%(54/80).The death group had higher positive rates of CBX2 and TIM3 in SACC tissues than the survival group(P<0.05).Patients with positive CBX2 and TIM3 in SACC tissues had clearly lower 5-year survival rate than patients with negative CBX2 and TIM3(Log Rank χ2=6.564,5.197,P<0.05).CBX2,TIM3 positivity,nerve invasion,and distant metastasis were risk factors affecting prognosis(P<0.05).Conclusion The positive expression of CBX2 and TIM3 in SACC tissues is closely related to the clinical pathological features and prognosis of patients.关键词
涎腺腺样囊性癌/色素框同源蛋白2/T细胞免疫球蛋白黏液素3/临床病理特征/预后Key words
salivary adenoid cystic carcinoma/CBX2/TIM3/clinical pathological features/prog-nosis分类
口腔医学引用本文复制引用
张璇,刘振丽,杨永超,马赛,刘博,吕红娟..涎腺腺样囊性癌组织色素框同源蛋白2、T细胞免疫球蛋白黏液素3表达水平及与患者临床病理特征、预后的关系[J].实用医学杂志,2025,41(12):1873-1878,6.基金项目
河北省医学科学研究课题计划(编号:20231445) （编号:20231445）
