日用化学工业（中英文）2025，Vol.55Issue(6)：756-766,11.DOI:10.3969/j.issn.2097-2806.2025.06.010
磷脂酰胆碱包裹的白藜芦醇增强皮肤抗氧化和抗皱能力研究
Phosphatidylcholine-encapsulated resveratrol augments skin's antioxidant and anti-wrinkle capabilities
帖航 1李琦 2朱翠翠 2袁旻嘉 2徐亮3
作者信息
- 1. 天津医科大学 药学院,天津 300222||中国检验检疫科学研究院粤港澳大湾区研究院,广东 中山 528400
- 2. 上海其然生物科技有限公司,上海 201702||上海缙嘉科技有限公司,上海 201210
- 3. 天津医科大学 药学院,天津 300222
- 折叠
摘要
Abstract
The objective of this research was to assess the potential of phosphatidylcholine-encapsulated resveratrol as a cosmetic ingredient.The hydrogen peroxide(H2O2)and ultraviolet A(UVA)induced human skin fibroblasts(HSF)models of skin damage were established to compare the antioxidant and anti-wrinkle properties between phosphatidylcholine-encapsulated resveratrol and unencapsulated resveratrol.The findings reveal that encapsulating resveratrol with phosphatidylcholine not only enhances skin absorption but also significantly improves its antioxidant capabilities.In the H2O2-induced HSF injury model,phosphatidylcholine-encapsulated resveratrol demonstrates a superior ability to neutralize reactive oxygen species(ROS)generated by H2O2 compared to the resveratrol group.Further analysis indicates that this enhanced functionality is associated with increased enzymatic activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and catalase(CAT)when treated with phosphatidylcholine-encapsulated resveratrol.Additionally,in UVA-irradiated HSF cells,phosphatidylcholine-encapsulated resveratrol effectively reduces the levels of matrix metalloproteinases-1 and-3(MMP-1 and MMP-3)and increased the contents of Collagen Ⅰ and Collagen Ⅲ(Col-1 and Col-3),demonstrating significant anti-wrinkle effects.These findings provide critical evaluation criteria and application references for enhancing cosmetic ingredients through phosphatidylcholine encapsulation,thereby advancing skincare formulations.关键词
磷脂酰胆碱包裹的白藜芦醇/白藜芦醇/人皮肤成纤维细胞/抗氧化/抗皱Key words
phosphatidylcholine-encapsulated resveratrol/resveratrol/human skin fibroblasts/antioxidant/anti-wrinkle分类
化学工程引用本文复制引用
帖航,李琦,朱翠翠,袁旻嘉,徐亮..磷脂酰胆碱包裹的白藜芦醇增强皮肤抗氧化和抗皱能力研究[J].日用化学工业（中英文）,2025,55(6):756-766,11.
