实用医学杂志2025，Vol.41Issue(12)：1907-1912,6.DOI:10.3969/j.issn.1006-5725.2025.12.020
骨质疏松症患者血清DKK-1、CTRP3水平对胸腰椎骨折的预测效能
The predictive efficacy of serum DKK-1 and CTRP3 levels for thoracolumbar fractures in patients with osteoporosis
摘要
Abstract
Objective To explore the predictive efficiency of serum Dickkopf-1 protein(DKK-1)and C1q tumor necrosis factor-related protein 3(CTRP3)levels for thoracolumbar fractures in patients with osteoporosis(OP).Methods Between January 2020 and August 2024,124 OP patients treated at the hospital were recruited into the OP group.Based on the occurrence of thoracolumbar fractures,these OP patients were divided into a non-fracture group(n=70)and a fracture group(n=54).Additionally,124 healthy individuals who underwent physical examinations served as the control group.The enzyme-linked immunosorbent assay(ELISA)was employed to measure the levels of serum DKK-1 and CTRP3.Multivariate logistic regression analysis was utilized to analyze the influencing factors of thoracolumbar fractures in OP patients.Receiver operating characteristic(ROC)curves were used to evaluate the predictive value of serum DKK-1 and CTRP3 for thoracolumbar fractures in OP patients.Results In comparison with the control group,the serum level of DKK-1 was significantly higher,while the serum level of CTRP3 was significantly lower in the OP group(P<0.05).When compared with the non-fracture group,the fracture group exhibited prominently higher serum DKK-1 levels,age,duration of OP,and proportion of OP grade Ⅲ,whereas the serum CTRP3 level was significantly lower(P<0.05).High expression of DKK-1 was iden-tified as an independent risk factor for thoracolumbar fractures in patients with osteoporosis,while high expression of CTRP3 was found to be an independent protective factor for thoracolumbar fractures in such patients(P<0.05).The area under the curve(AUC)values of serum DKK-1 and CTRP3 levels for predicting thoracolumbar fractures in OP patients were 0.790 and 0.753,respectively.The AUC of the combined prediction of the two was 0.888,which was superior to the individual predictions of either one(ZDKK-1-combined=3.351,ZCTRP3-combined=3.172,both P<0.05).Conclusions In the serum of OP patients,the expression of DKK-1 is upregulated,while the expression of CTRP3 is downregulated.Both are factors influencing the occurrence of thoracolumbar fractures in OP patients.The combination of the two has a high predictive value for the occurrence of thoracolumbar fractures in OP patients.关键词
骨质疏松症/胸腰椎骨折/Dickkopf-1蛋白/C1q肿瘤坏死因子相关蛋白3/预测效能Key words
osteoporosis/thoracolumbar fracture/Dickkopf-1 protein/C1q tumor necrosis factor related protein 3/predictive efficiency分类
医药卫生引用本文复制引用
常乐,周丹微,顾小琼..骨质疏松症患者血清DKK-1、CTRP3水平对胸腰椎骨折的预测效能[J].实用医学杂志,2025,41(12):1907-1912,6.基金项目
江苏省老年健康科研项目(编号:LKM2022071) （编号:LKM2022071）
苏州市卫生健康委员会科技项目(编号:LCZX202344) （编号:LCZX202344）
