实用医学杂志2025，Vol.41Issue(12)：1929-1935,7.DOI:10.3969/j.issn.1006-5725.2025.12.023
嗜神经侵袭在妇科恶性肿瘤中的研究进展
Research progress of perineural invasion in gynecological malignant tumors
摘要
Abstract
As a distinct pathological factor and metastatic route of malignant tumors,perineural invasion(PNI)exhibits a close association with the prognosis of several cancer types.In recent years,the clinical significance and underlying mechanisms of PNI in gynecological malignant tumors have increasingly drawn research attention.Currently,it is recognized that PNI is clinicopathologically and prognostically linked to cervical cancer and vulvar cancer.The exploration of its mechanisms encompasses multiple gynecological tumors and numerous molecular pathways,including the CCL2/CCR2 axis,NGF/TrkA pathway,GluR2,among others.Nevertheless,the existing research models are fragmented,lacking systematicity and in-depth analysis,thus necessitating integration.This paper presents a comprehensive review of the occurrence of PNI in gynecologic malignancies,its correlations with clinicopathology and prognosis,its implications for surgical approaches and postoperative adjuvant therapies,as well as the potential molecular mechanisms.By synthesizing the advancements in both clinical and basic research,this review aims to offer a solid theoretical foundation for further exploration of the mechanisms underlying PNI in gynecologic malignancies and for the optimization of clinical therapeutic strategies.关键词
嗜神经侵袭/宫颈癌/外阴癌/卵巢癌/子宫内膜癌Key words
perineural invasion/cervical cancer/vulvar carcinoma/ovarian cancer/endometrial cancer分类
医药卫生引用本文复制引用
何业坤,龙颖,岑立仗,姚德生..嗜神经侵袭在妇科恶性肿瘤中的研究进展[J].实用医学杂志,2025,41(12):1929-1935,7.基金项目
国家自然科学基金项目(编号:81760466) （编号:81760466）
广西自然科学基金项目(编号:2022GXNSFBA035476) （编号:2022GXNSFBA035476）
