日用化学工业（中英文）2025，Vol.55Issue(6)：779-784,6.DOI:10.3969/j.issn.2097-2806.2025.06.012
天麻素对UVB损伤皮肤的修复作用
Repairing effect of gastrodin on UVB-damaged skin
厉浩东 1吴兴怡 1张影 1王玮恋 1王伟 2李丽1
作者信息
- 1. 北京工商大学 北京市植物资源重点实验室,北京 100048
- 2. 润芳可(上海)生物科技有限公司,上海 201400
- 折叠
摘要
Abstract
In order to investigate the reparative effect of gastrodin(GAS)in the skin damaged by medium-wave ultraviolet(UVB)rays,human keratinocytes(HaCaT)was used to build UVB radiation damage cell model.The inhibitory effect of GAS on the secretion of TNF-α and PGE2 in UVB-irradiated cells,and the modulation of the mRNA expression levels of AQP3 and FLG,as well as the effects on the content of the two proteins,were investigated by enzyme-linked immunosorbent assay(ELISA),real-time quantitative fluorescence PCR(qRT-PCR),and immunofluorescent assays.The results show that GAS solution at a mass concentration of 200µg/mL can repair the inflammatory damage produced by UVB,inhibit the secretion of TNF-α and PGE2(P<0.05 and P<0.001),up-regulate the mRNA expression levels of FLG and AQP3(P<0.01 and P<0.05),and increase the protein content of FLG and AQP3(P<0.01 and P<0.001).It elevates the skin hydration and promotes the repair of the skin barrier function,thus reinforcing the barrier structure,which can provide scientific experimental basis for the application of GAS in restorative cosmetics.关键词
天麻素/中波紫外线/人角质形成细胞/皮肤修复Key words
gastrodin/UVB/HaCaT/skin repair分类
化学化工引用本文复制引用
厉浩东,吴兴怡,张影,王玮恋,王伟,李丽..天麻素对UVB损伤皮肤的修复作用[J].日用化学工业（中英文）,2025,55(6):779-784,6.
