实用医学杂志2025，Vol.41Issue(12)：1936-1944,9.DOI:10.3969/j.issn.1006-5725.2025.12.024
线粒体稳态在血管性认知障碍中的研究进展
Research progress on mitochondrial homeostasis in vascular cognitive impairment
摘要
Abstract
Vascular cognitive impairment(VCI)is a type of cognitive dysfunction caused by cerebrovascular lesions,and its pathological mechanism includes mitochondrial damage.Therefore,maintaining mitochondrial homeostasis is crucial in the occurrence and progression of VCI.Mitochondrial homeostasis involves multiple levels,including biogenesis,autophagy,ion balance,protein quality control,membrane dynamics,and interactions with other organelles.This study outlines the regulatory mechanisms of mitochondrial homeostasis dysregulation at both the micro and macro levels,delves into the key role of mitochondrial homeostasis in VCI,analyzes potential therapeutic directions,and provides new scientific evidence and perspectives for the early diagnosis and treatment of VCI.关键词
血管性认知障碍/线粒体稳态/线粒体生物学/神经保护Key words
vascular cognitive impairment/mitochondrial homeostasis/mitochondrial biology/neu-roprotection分类
医药卫生引用本文复制引用
戴玲慧,李伟峰..线粒体稳态在血管性认知障碍中的研究进展[J].实用医学杂志,2025,41(12):1936-1944,9.基金项目
第七批全国老中医药专家学术经验继承工作项目(编号:国中医药人教函[2022]76号) （编号:国中医药人教函[2022]76号）
河南省科技攻关项目(编号:242102310514) （编号:242102310514）
河南省中医药科学研究专项课题(编号:2024ZY1006,2024ZY1028,2024ZY2068) （编号:2024ZY1006,2024ZY1028,2024ZY2068）
河南省中医药科学研究专项课题重大专项(编号:2022ZYZD05) （编号:2022ZYZD05）
