生殖医学杂志2025，Vol.34Issue(6)：777-783,7.DOI:10.3969/j.issn.1004-3845.2025.06.008
供受卵双方IVF/ICSI-ET临床结局的比较及影响因素分析
Comparison of clinical outcomes of IVF/ICSI-ET between oocyte donors and recipients and analysis of influencing factors
摘要
Abstract
Objective:To analyze the clinical outcomes and related influencing factors of IVF/ICSI-ET for both oocyte donors and recipients in order to provide more references for the selection of oocyte donation plans. Methods:A retrospective analysis was conducted on the clinical data of 159 donors(the donor group)and 209 recipients(the recipient group)who underwent IVF/ICSI-ET treatment in the Department of Reproductive Medicine at Eastern Theater Command Hospital from January 2019 to August 2024.The basic information,blastocyst culture,and pregnancy outcomes of the donors and recipients were analyzed.The differences in the number of frozen embryos,cumulative pregnancy rate,and cumulative live birth rate were analyzed among oocyte donors with different numbers of self-used oocytes after oocyte donation. Results:The comparison of basic data between the two groups showed that the age,infertility duration,and baseline FSH level of the recipient were significantly higher than those of the donor group(P＜0.05).The recipients were all fertilized using ICSI,and the proportion of ICSI was significantly higher than that of the donor group(P＜0.05).The normal fertilization rate(85.65％vs.69.92％),high-quality embryo rate(72.91％vs.63.55％),and blastocyst formation rate(74.29％vs.66.53％)of the recipient group were significantly higher than those of the donor group(P＜0.05),and the rate of cycle cancellation without available embryos was also significantly higher than that of the donor group(P＜0.05).The donor group underwent a total of 224 cycles of embryo transfer[22 cycles for fresh embryo transfer and 202 cycles for freeze-thaw embryo transfer(FET)],while the recipient group underwent a total of 131 cycles of FET transfer.There was no significant difference in clinical pregnancy rate,live birth rate,and early miscarriage rate between the two groups(P＞0.05),but the cumulative pregnancy rate(91.89％vs.60.66％)and cumulative live birth rate(64.19％vs.40.16％)of the donor group were significantly higher than those of the recipient group(P＜0.05).Stratified analysis of oocyte donors based on the number of self-used oocytes after donation showed that the number of frozen embryos in the 15-20 self-used oocyte group was significantly lower than those in the 21-25,26-30,and more than 30 groups(P＜0.05).There was no significant difference in the cumulative pregnancy rate between groups among different numbers of oocytes(P＞0.05),but the cumulative pregnancy rate gradually decreased when the number of self-used oocytes exceeded 25.The cumulative live birth rates of the self-use oocyte groups with 26-30 oocytes and more than 30 oocytes were significantly lower than that of the group with 21-25 oocytes(48.57％,50.00％vs.76.47％,P＜0.05). Conclusions:Providing 2-4 oocytes has no effect on the pregnancy outcome of the donor.The clinical pregnancy outcomes could be achieved with satisfaction when a recipient receives 2 mature(MⅡ)oocytes per cycle and is fertilized using ICSI.关键词
冻融胚胎移植/供卵/受卵/妊娠结局Key words
Freeze-thaw embryo transfer/Oocyte donation/Oocyte recipient/Pregnancy outcome分类
临床医学引用本文复制引用
林莹,陈莉,唐旭,伏海燕,吴蓉花,李晓艳,许娟娟..供受卵双方IVF/ICSI-ET临床结局的比较及影响因素分析[J].生殖医学杂志,2025,34(6):777-783,7.基金项目
东部战区总医院院管课题(22LCZLXJS29) （22LCZLXJS29）
江苏省医学重点学科建设单位项目(JSDW202215) （JSDW202215）
江苏省卫生健康委科研项目(ZD2022004) （ZD2022004）
