现代妇产科进展2025，Vol.34Issue(6)：429-436,8.DOI:10.13283/j.cnki.xdfckjz.2025.06.003
一项基于SEER数据库的子宫内膜浆液性癌临床病理特征和预后关系的回顾性研究
Clinicopathological characteristics and prognosis of uterine serous carcinoma:a SEER-based retrospective study
摘要
Abstract
Objective:To investigate the correlation between the clinicopathological characteristics and survival time among USC patients.Method:By using the Surveillance,Epi-demiology and End Results(SEER)database,we retrospectively identified and evaluated the clinicopathological variants and survival time of USC patients from 2000 to 2016.Univariable and multivariable Cox regressions were applied to evaluate the effects of clinical variables on survival.Kaplan-Meier plots were used to visually demonstrate the correlation between inde-pendent risk factors and survival.Results:Clinical and pathological data from 1437 patients in the SEER database were included in this study.The overall survival(OS)rates of the study population were 86.08%(1237/1437)at 1 year,61.10%(878/1437)at 3 years,and 48.16%(692/1437)at 5 years.Univariate Cox regression analysis revealed that age>60 years,advanced stage,regional lymph node metastasis,distant metastasis,unmarried status,no surgery,no radiotherapy,no chemotherapy,and larger tumor size were significantly associated with reduced OS and cancer-specific survival(CSS)(all P<0.05).Multivariate Cox regression analysis identified age>60 years,distant metastasis,advanced tumor stage,and larger tumor size as independent prognostic factors for worse OS and CSS in uterine serous carcinoma(all P<0.05).Conversely,being married,postoperative chemotherapy,postoperative radiotherapy,sur-gery,and adjuvant chemoradiotherapy were independent favorable prognostic factors for both OS and CSS(all P<0.05).Lymph node metastasis had no significant impact on OS or CSS(P>0.05).Kaplan-Meier curve analysis demonstrated that surgical treatment,radiotherapy,and ad-juvant chemoradiotherapy significantly improved both OS and CSS(all P<0.05).Chemothera-py was associated with improved OS(P<0.05)but had no significant benefit on CSS(P>0.05).Additionally,age>60 years significantly increased mortality and reduced both OS and CSS(P<0.05).Conclusion:This study identified several independent prognostic predictors for uterine serous carcinoma,providing valuable insights for evaluating patient outcomes.Our find-ings emphasize the importance of encouraging surgical intervention and postoperative adjuvant chemoradiotherapy,which may significantly prolong survival and confer clinical benefits.These results offer guidance for clinicians in prognostic assessment and establish a foundation for opti-mizing therapeutic strategies in uterine serous carcinoma management.关键词
子宫内膜浆液性癌/临床病理特征/危险因素/生存期Key words
Uterine serous carcinoma/Clinicopathological Characteristics/Risk fac-tors/Survival分类
临床医学引用本文复制引用
王圆圆,关新垒,苗梦薇,杜昕,晋孟伟,秦海霞..一项基于SEER数据库的子宫内膜浆液性癌临床病理特征和预后关系的回顾性研究[J].现代妇产科进展,2025,34(6):429-436,8.基金项目
河南省医学科技攻关计划联合共建项目(No:LHGI20230513) （No:LHGI20230513）
新乡市妇科恶性肿瘤智能化精准诊疗工程技术研究中心 （）
