现代妇产科进展2025，Vol.34Issue(6)：437-440,4.DOI:10.13283/j.cnki.xdfckjz.2025.06.004
上皮性卵巢癌CapG表达与Treg细胞浸润及患者预后的相关性研究
Correlation study of CapG expression with Treg infiltration and patient prognosis in epi-thelial ovarian cancer
陆灿灿 1张晶晶 2金银瑛 1杨欣 1乔涵1
作者信息
- 1. 青岛大学医学部,青岛 266071||青岛大学附属医院妇科,青岛 266100
- 2. 青岛大学附属医院妇科,青岛 266100
- 折叠
摘要
Abstract
Objective:To investigate the correlation between macrophage capsidized protein(CapG)expression and regulatory T cell(Treg)infiltration in epithelial ovarian cancer(EOC)and patient prognosis.Methods:CapG expression and Treg cell infiltration in EOC,be-nign ovarian tumors and normal ovarian tissues were detected by immunohistochemistry to inves-tigate the relationship between CapG expression and Treg cell infiltration and the clinicopatho-logical features and prognosis of EOC,and to analyze the correlation between CapG expression and Treg cell infiltration.Results:The expression of CapG in EOC was significantly higher than that in benign ovarian tumor tissues and normal ovarian tissues,and the expression of CapG was correlated with tumor stage,grading and the presence of lymph node metastasis.Treg cell infil-tration was significantly up-regulated in EOC compared with that in benign ovarian tumor tissues and normal ovarian tissues,which was correlated with EOC stage,grading,the presence of lymph node metastasis and the pathological type.The expressions of CapG and Treg cell infiltration were significantly correlated with the clinical and pathological characteristics and prognosis of EOC.The relationship between CapG expression and Treg cell infiltration was analyzed.CapG expression and Treg cell infiltration in EOC showed a significant positive correlation,and CapG expression and Treg cell infiltration were associated with poor prognosis of EOC.Conclusion:CapG and Treg cells may be involved in the development of EOC,which is expected to be a predictive indicator of EOC prognosis.关键词
上皮性卵巢癌/巨噬细胞加帽蛋白/调节性T细胞/预后Key words
Epithelial ovarian cancer/Gelsolin-like actin-capping protein/Regulatory T cell/Prognosis分类
临床医学引用本文复制引用
陆灿灿,张晶晶,金银瑛,杨欣,乔涵..上皮性卵巢癌CapG表达与Treg细胞浸润及患者预后的相关性研究[J].现代妇产科进展,2025,34(6):437-440,4.
