现代妇产科进展2025，Vol.34Issue(6)：441-447,7.DOI:10.13283/j.cnki.xdfckjz.2025.06.005
妊娠期无创血流动力学变化趋势及其对新生儿体重的影响
Non-invasive hemodynamic changes during pregnancy and their effect on neonatal birth weight
摘要
Abstract
Objective:To investigate the trends of non-invasive hemodynamic parame-ters during pregnancy and their impact on fetal birth weight.Methods:A retrospective analysis was conducted on the non-invasive hemodynamic test results of 1 839 pregnant women who un-derwent prenatal checkups at hospital from June 2024 to January 2025.The trends of non-inva-sive hemodynamic parameters were analyzed for 713 women in the first trimester(8～13 weeks),481 women in the second trimester(14～27 weeks),and 645 women in the third tri-mester(28～36 weeks).Maternal and fetal data from 648 pregnant women with pregnancy out-comes were collected to preliminarily explore the impact of non-invasive hemodynamic parame-ters in the first,second,and third trimesters on fetal birth weight.Results:During the first,sec-ond,and third trimesters,there was no significant change in stroke volume(SV)among pregnant women(P>0.05).However,significant changes were observed in heart rate(HR),cardiac out-put(CO),systemic vascular resistance index(SVRi),systemic vascular resistance(SVR),and mean brachial artery pressure(MBAP)(all P<0.05).HR and CO showed a positive correlation with gestational age,while SVR and SV exhibited a negative correlation(all P<0.05).Among the 648 pregnant women with pregnancy outcomes,551(85.0%)delivered appropriate-for-ges-tational-age(AGA)infants,43(6.6%)delivered large-for-gestational-age(LGA)infants,and 54(8.3%)delivered small-for-gestational-age(SGA)infants.A comparison among the three groups revealed that cardiac timing index(CTI)showed a consistent trend from early to late pregnancy:the CTI of women who delivered LGA infants was significantly lower than that of the AGA and SGA groups.Multivariable logistic regression analysis yielded the following significant findings:Mid-trimester CTI demonstrated a significant inverse association with fetal birth weight categories.Specifically,each unit increase in CTI was associated with a 1.4%reduction in the likelihood of advancing to a higher birth weight category(e.g.,transitioning from AGA to LGA or from SGA to AGA)(OR=0.986,95%CI:0.976～0.996).Third-trimester HR showed a positive correlation with birth weight classification progression.Each 1-beat-per-minute increase in maternal HR was associated with a 5%greater probability of the newborn being classified in-to a higher weight category(e.g.,progression from AGA to LGA)(OR=1.05,95%CI:1.006～1.096).Conclusion:Non-invasive hemodynamic parameters undergo significant changes as pregnancy progresses.The non-invasive hemodynamic indices CTI and HR are significantly as-sociated with fetal growth and development.关键词
妊娠/无创血流动力学/变化趋势/胎儿生长发育Key words
Pregnancy/Non-invasive hemodynamics/Trends/Fetal growth and devel-opment分类
临床医学引用本文复制引用
俞露,郑燕伟,李毓,贺春雨,李明,李婷,周月娣,王娟,蒋荣珍..妊娠期无创血流动力学变化趋势及其对新生儿体重的影响[J].现代妇产科进展,2025,34(6):441-447,7.基金项目
上海市第六人民医院院级课题(No:ynhg202126 （）
No:ynhg202428) （）
