现代医药卫生2025，Vol.41Issue(6)：1315-1318,4.DOI:10.3969/j.issn.1009-5519.2025.06.005
病毒性脑炎患者灌注改变与发生癫痫及预后不良的相关性研究
Correlation of perfusion changes with epilepsy and poor prognosis in patients with viral encephalitis
摘要
Abstract
Objective To investigate the correlation of perfusion changes with epilepsy and poor prog-nosis in patients with viral encephalitis by three-dimensional arterial spin labeling(3D-ASL)perfusion tech-nique.Methods A total of 102 patients with viral encephalitis who were hospitalized in Jiangsu Subei people's Hospital from January 2017 to May 2024 were selected and divided into normal perfusion group(NP group),focal hypoperfusion group(LF group),diffuse hypoperfusion group(LE group),focal hyperperfusion group(HF group)and diffuse hyperperfusion group(HE group).The incidence of poor prognosis and epilepsy in each group,as well as the influencing factors of epilepsy and poor prognosis in patients with encephalitis were analyzed.Results There was no significant difference in the time from onset to MRI scan among the five groups(P=0.742).The incidence of epilepsy and poor prognosis in NP group,LF group,LE group,HF group and HE group were 14.3%(2/14)and 21.4%(3/14),46.7%(7/15)and 33.3%(5/15),33.3%(3/9)and 55.6%(5/9),50.0%(22/44)and 20.5%(9/44),35.0%(7/20)and 35.0%(7/20),respectively.Gender and age were not the influencing factors of epilepsy in patients with viral encephalitis(P>0.05),while perfusion pattern was related to the risk of epilepsy.The risk of epilepsy in HF group was 6.217 times higher than that in NP group(P=0.027).Age was significantly correlated with the prognosis of patients with viral encephalitis(P<0.05),while perfusion pattern and gender were not correlated with the prognosis(P>0.05).The proba-bility of poor prognosis in patients with viral encephalitis increased by 1.045 times with the increase of age by one year(P=0.003).Conclusion In patients with viral encephalitis,patients with focal hyperperfusion on 3D-ASL images are more likely to have epilepsy,and the older patients are more likely to have poor prognosis.关键词
病毒性脑炎/三维动脉自旋标记/脑灌注显像/癫痫Key words
Viral encephalitis/Three-dimensional arterial spin labeling/Cerebral perfusion ima-ging/Epilepsy分类
临床医学引用本文复制引用
张梦玲,朱艳,于海龙,仲星星,李想,刘佩佩..病毒性脑炎患者灌注改变与发生癫痫及预后不良的相关性研究[J].现代医药卫生,2025,41(6):1315-1318,4.基金项目
中国博士后科学基金项目(2022M711416). （2022M711416）
