现代医药卫生2025，Vol.41Issue(6)：1358-1361,1367,5.DOI:10.3969/j.issn.1009-5519.2025.06.015
血清VEGF、HIF-2α表达与分化型甲状腺癌腔镜根治术后复发的关系
The relationship between the expression of serum VEGF and HIF-2α and the recurrence of differentiated thyroid cancer after laparoscopic radical resection
郭东慧 1孙永强 1马书仁1
作者信息
- 1. 郑州市第三人民医院甲状腺乳腺外科,河南 郑州 450000
- 折叠
摘要
Abstract
Objective To investigate the relationship between the expression of serum vascular endo-thelial growth factor(VEGF)and hypoxia-inducible factor-2α(HIF-2α)and the recurrence of differentiated thyroid cancer after laparoscopic radical resection.Methods A total of 81 thyroid cancer patients who under-went endoscopic radical surgery for thyroid cancer admitted to our hospital from February 2017 to February 2019 were retrospectively analyzed,and the patients were divided into the non-recurrence group(68 cases)and the recurrence group(13 cases)according to their recurrence status within 5 years after surgery.Serum VEGF and HIF-2α levels were detected in both groups before surgery,and general data of the two groups were recor-ded to analyze the correlation between serum VEGF and HIF-2α levels and postoperative outcome of patients with thyroid cancer,as well as the predictive value of serum VEGF and HIF-2α detection on postoperative out-come of patients with thyroid cancer.Results The tumor diameter and TNM stage of the non-recurrence group were compared with those of the recurrence group(P<0.05).The levels of serum VEGF and HIF-2α in the non-recurrence group were lower than those in the recurrence group(P<0.05).Through Cox regres-sion analysis,the results showed that TNM staging,tumor diameter,serum VEGF and HIF-2α were associated with postoperative outcomes in thyroid cancer patients(P<0.05).The area under the working characteristic curve of serum VEGF and HIF-2α were all greater than 0.7 for predicting the postoperative outcome of pa-tients with thyroid cancer,which had certain predictive value.Conclusion Serum VEGF and HIF-2α are close-ly related to postoperative outcomes in thyroid cancer patients and have certain predictive value.关键词
甲状腺肿瘤/血管内皮生长因子类/缺氧诱导因子-2α/外科手术/手术后期间/复发Key words
Thyroid tumor/Vascular endothelial growth factors/Hypoxia inducible factor-2α/Surgical operative/Postoperative period/Recurrence分类
医药卫生引用本文复制引用
郭东慧,孙永强,马书仁..血清VEGF、HIF-2α表达与分化型甲状腺癌腔镜根治术后复发的关系[J].现代医药卫生,2025,41(6):1358-1361,1367,5.
