摘要
Abstract
Objective To analyze the comorbidity characteristics of chronic diseases and the status of potentially inappropriate medication(PIM)in elderly patients with osteoporosis(OP),so as to provide basis for promoting rational drug use in elderly patients with OP.Methods A total of 229 elderly patients diag-nosed with OP in the department of orthopedics of the hospital from January 1,2024 to May 31,2024 were retrospectively selected.The comorbidity and PIM of patients were analyzed.The CCI score and polypharmacy of patients with different gender and age were compared,and the correlation between chronic comorbidity,CCI score and PIM was discussed.Results Among 229 patients,135 cases were complicated with two or more complications,67 cases with one complication and 27 cases without complications.Patients had 11 co-morbidi-ties and the top three were hypertension(53.28%),diabetes(22.27%)and cerebral infarction(21.40%).The patients'CCI scores ranged from 0 to 10,with a median of 2(1,3).There was no significant difference in CCI scores between patients with different genders(P>0.05).There was significant difference in CCI scores among patients of different ages(P<0.05).There was no significant difference in polypharmacy among pa-tients of different ages(P>0.05).There were 13 kinds of drugs used by patients,with a median of 5(4,7).A total of 76 patients had PIM,with 106 times,and the incidence rate was 33.19%.PIM was weakly positively correlated with the number of chronic comorbidities(r=0.338,P<0.001)and CCI score(r=0.305,P=0.002),and moderately positively correlated with the number of combination therapy(r=0.423,P<0.001)and polypharmacy(r=0.409,P=0.001),while there was no correlation with gender and age(P>0.05).Con-clusion The CCI score,the incidence of polypharmacy and PIM are higher in elderly OP patients,and PIM is positively correlated with them.关键词
老年/骨质疏松症/共病/不合理用药Key words
Elderly/Osteoporosis/Comorbidity/Potentially inappropriate medication分类
医药卫生
