纤维素科学与技术2025，Vol.33Issue(2)：8-22,15.DOI:10.16561/j.cnki.xws.2025.02.06
PVDF微纳纤维增强型BNC氧合膜的制备及其表征
Preparation and Characterization of PVDF Micro-nano Fiber Reinforced BNC Oxygenation Membranes
摘要
Abstract
The oxygenation membrane is a key component of membrane oxygenators.Currently,commercially available oxygenation membranes suffer from poor biocompatibility and insufficient oxygen permeability.Therefore,there is an urgent need to develop new types of blood oxygenation membranes to address these issues.Bacterial nanocellulose(BNC)has good biocompatibility,and its three-dimensional structure can be used for oxygen transport.However,the mechanical and oxygen permeation properties of BNC still need to be improved.To improve the mechanical properties and oxygen permeability of bacterial nanocellulose membranes and expand their applications in medical materials and functional materials,a PVDF/BNC composite membrane was fabricated using BNC as the substrate and polyvinylidene fluoride(PVDF)electrospun micro-nano fibers as reinforcement.The morphological structure of the composite was characterized by scanning electron microscopy.Further investigations were conducted on the mechanical properties,oxygen permeability,peel strength,plasma penetration,and other performance metrics of the PVDF electrospun fiber membrane and PVDF/BNC composite,along with evaluations of their blood and cell compatibility.The results demonstrated that the PVDF/BNC composite membrane achieved a burst pressure of 30 kPa(225 mmHg),three times that of pure BNC,and an oxygen permeability of 40 mL·m⁻²·min⁻¹,four times higher than BNC.The plasma osmotic pressure reached 20 kPa(150 mmHg),twice that of BNC,while the tensile strength and Young's modulus were significantly superior to BNC.The composite exhibited excellent blood compatibility,and the incorporation of PVDF electrospun fibers enhanced material porosity and improved cell compatibility.These experimental findings highlight the potential of BNC-based composite membranes for oxygenation membrane applications.关键词
细菌纤维素/静电纺丝/氧合膜/聚偏二氟乙烯/透氧性Key words
bacterial nanocellulose,electrospinning/oxygenation membrane/polyvinylidene fluoride/oxygen permeability引用本文复制引用
吴璐璐,林露露,陈琳,洪枫..PVDF微纳纤维增强型BNC氧合膜的制备及其表征[J].纤维素科学与技术,2025,33(2):8-22,15.基金项目
国家自然科学基金(32171405). （32171405）
