新医学2025，Vol.56Issue(6)：613-620,8.DOI:10.12464/j.issn.0253-9802.2024-0505
胰高血糖素样肽-1受体激动剂在肥胖和食物成瘾治疗中的作用机制
Mechanism of glucagon-like peptide-1 receptor agonist in the treatment of obesity and food addiction
摘要
Abstract
Obesity and food addiction have become major threats to public health,and their synergistic interactions exacerbate metabolic abnormalities and comorbidities.Glucagon-like peptide-1 receptor agonist(GLP-1RA)has emerged as a promising therapeutic option for these conditions,and their mechanism of action has become a major research focus.Evidence indicates that GLP-1RA suppress appetite and delay gastric emptying through central and peripheral pathways.Furthermore,they modulate mesolimbic dopamine system(MLDS),reduce the release of dopamine in the nucleus accumben,attenuate the rewarding effects of high-calorie foods and ameliorate addictive eating behaviors,thereby treating obesity.However,adverse gastrointestinal effects and potential long-term risks of GLP-1RA necessitate cautious clinical management.In this article,recent clinical advances in the application of GLP-1RA applications for the treatment of obesity and food addiction were reviewed,providing reference for drug selection for obesity and food addiction.关键词
胰高血糖素样肽-1受体激动剂/肥胖/食物成瘾/中脑边缘多巴胺系统Key words
GLP-1RA/Obesity/Food addiction/Mesolimbic dopamine system引用本文复制引用
刘璐瑶,李林蔚,王晨,狄建忠..胰高血糖素样肽-1受体激动剂在肥胖和食物成瘾治疗中的作用机制[J].新医学,2025,56(6):613-620,8.基金项目
国家自然科学基金(82370901) （82370901）
