中国康复2025，Vol.40Issue(6)：332-337,6.DOI:10.3870/zgkf.2025.06.002
间歇性Theta爆发式刺激联合正中神经电刺激对卒中后认知障碍的影响
Effect of iTBS combined with median nerve electrical stimulation on post-stroke cognitive impairment
摘要
Abstract
Objective:To investigate the influences of intermittent Theta burst stimulation(iTBS)in combination with median nerve electrical stimulation(MNS)on the cognitive function of patients with post-stroke cognitive im-pairment(PSCI).Methods:Totally,45 patients with PSCI were chosen as the research subjects and were catego-rized into the combined treatment group,the iTBS group,and the control group via the random number table meth-od,with 15 cases in each group.All the patients in the three groups received conventional rehabilitation therapy.Based on this,the combined treatment group received both MNS and iTBS treatment,the iTBS group received only iTBS treatment,and the control group received conventional rehabilitation treatment.iTBS,MNS,and conventional rehabilitation treatment were all provided once a day,5 times a week,for a total duration of 4 weeks.Before and af-ter the treatment,the Montreal Cognitive Assessment Scale(MoCA),the Loewenstein Occupational Therapy Cog-nitive Assessment Scale(LOTCA),and quantitative electroencephalogram[including power spectral density(PSD)and slow wave ratio(DTABR)]were employed to compare the therapeutic effects of cognitive function among the three groups.Results:After the treatment,all three groups exhibited improvement on the scores of the Mo-CA and LOTCA compared to before(P＜0.05).Com-pared with the control group and iTBS group,Moca and LOCTA in the combination group were significantly inscreased(P＜0.05).After treatment,The PSD and DTABR combined group and iTBS groups were im-proved significantly(P＜0.05),and the combined group was optimal(P＜0.05).Conclusion:The thera-peutic effect of iTBS combined with MBS on the cogni-tive function recovery in PSCI patients is better than the single iTBS treatment.关键词
卒中后认知障碍/间歇性θ爆发式刺激/正中神经电刺激/脑电图/功率谱密度/蒙特利尔认知评估量表/洛文斯顿认知评定量表Key words
post-stroke cognitive impairment/intermittent Theta burst stimulation/median nerve electrical stim-ulation/electroencephalogram/power spectral density/Montreal cognitive assessment/Loewenstein occupational therapy cognitive assessment分类
临床医学引用本文复制引用
陈秋宇,王世雁,巩尊科,林子芊,王翔,陈晓宇..间歇性Theta爆发式刺激联合正中神经电刺激对卒中后认知障碍的影响[J].中国康复,2025,40(6):332-337,6.基金项目
徐州市科技局重点研发计划(社会发展)-医药卫生面上项目(KC23190) （社会发展）
